伊伐布雷定治疗慢性阻塞性肺疾病合并心绞痛患者的临床观察  

Clinical observation of effect of Ivabradine in the treatment of patients with chronic obstructive pulmonary disease complicated with angina pectoris

作　　者：郝骥[1] 李新立[2] 祁春梅[1] 冯建启[1] 彭城[1] 

机构地区：[1]徐州医学院第二附属医院(徐州矿务集团总医院)心内科,221002 [2]南京医科大学第一附属医院心内科,210029

出　　处：《中国心血管杂志》2016年第6期475-477,共3页Chinese Journal of Cardiovascular Medicine

摘　　要：目的观察伊伐布雷定对慢性阻塞性肺疾病合并心绞痛患者的临床安全性及治疗效果。方法临床诊断慢性阻塞性肺疾病合并心绞痛患者32例,随机分成常规药物治疗组(对照组)和常规药物加伊伐布雷定治疗(5mg 2次/d)组(观察组)各16例。入组前测量患者心率、行Borg呼吸困难评分、6min步行试验并记录一周内发作心绞痛的次数。分别在第1、4、12周时复测上述指标。结果在对照组,第12周时患者心绞痛发作次数减少;在观察组,第1、4、12周时患者心室率下降,第4、12周时心绞痛发作次数较前减少、6min步行试验距离较前增加;与对照组相比,观察组在第1、4、12周时患者心室率下降、第4、12周时6min步行试验距离增加及心绞痛发作次数减少;两组患者用药前后及两组之间Borg呼吸困难评分无明显变化。结论伊伐布雷定用于治疗慢性阻塞性肺疾病合并心绞痛患者安全有效,常规药物治疗基础上可进一步改善临床症状。Objective To investigate the safety and efficacy of Ivabradine in treatment of patients with chronic obstructive pulmonary disease （ COPD） complicated with angina pectoris . Methods A total of 32 patients with COPD and angina pectoris were randomly divided into two groups ：routine drug treatment group （control group） and Ivabradine （5 mg,twice daily） treatment group （observation group）,16 patients in each group.Heart rates （HR）,Borg scores,6 minutes walk test （6MWT） and the onset times of angina pectoris were recorded one week before enrollment and 1,4 and 12 weeks after treatment. Results In control group ,the episodes of angina pectoris was reduced after 12 weeks.In Ivabradine group ,HR decreased at 1,4 and 12 weeks after treatment ,episodes of angina pectoris reduced and the distance of 6MWT increased at 4 and 12 weeks after treatment.Compared with the control group ,HR was lower while episodes of angina pectoris reduced and the distance of 6MWT increased significantly in Ivabradine group at 1,4 and 12 weeks after treatment.Borg scores did not show significant difference between the 2 groups. Conclusions Ivabradine is safe and effective for the patients with COPD complicated with angina pectoris .Clinical symptoms could be improved by Ivabradine on the basis of routine medication .

关 键 词：伊伐布雷定 肺疾病 慢性阻塞性 心绞痛 6 MIN步行试验 

分 类 号：R541.4[医药卫生—心血管疾病] R563.9[医药卫生—内科学]