男性年龄与体外受精-胚胎移植治疗结局的相关性分析  

Correlation between paternal age and clinical outcomes of IVF-ET

作　　者：王晟[1] 郐艳荣[1] 贺占举[2] 张凯[1] 曾诚[1] 薛晴[1] 尚鶄[1] 杨秀丽[1] 陈亮[1] 陈菲[1] 鞠慧岩[1] 徐阳[1] WANG Sheng KUAI Yanrong HE Zhanju ZHANG Kail ZENG Cheng XUE Qing SHANG Jing YANG Xiuli CHEN Liang CHEN Fei JU Huiyan XU Yang(Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China Department of Urology, Peking University First Hospital, Beijing 100034, China)

机构地区：[1]北京大学第一医院妇产科,北京100034 [2]北京大学第一医院泌尿科,北京100034

出　　处：《中国性科学》2016年第12期90-94,共5页Chinese Journal of Human Sexuality

摘　　要：目的：探讨男性年龄对体外受精-胚胎移植（IVF-ET）治疗结局的影响。方法：按照男方年龄将接受常规IVF-ET治疗的188对夫妇分为四组：年龄〈31岁组53例,31~35岁组78例,36~40岁组37例,〉40岁组20例。分析男方年龄对IVF-ET治疗结局的影响。结果：本研究中各组间女方年龄、不孕年限、内膜厚度、基础FSH值、Gn总量、获卵总数、MII卵数、可移植胚胎率、优质胚胎率等结果比较均无显著性差异（P〉0.05）,男方精液体积、精子密度、前向运动精子比率均无明显差异（P〉0.05）,36~40岁组（9.3±3.0）和〉40岁组（9.5±2.6）的正常形态精子比率显著低于〈31岁组（13.5±2.8）和31~35岁组（12.6±2.7）（P〈0.05）,而且36~40岁组的受精率（76.6%）显著低于〈31岁组（83.1%）和31~35岁组（81.4%）（P〈0.05）。另外,〈31岁、31~35岁、36~40岁、〉40岁组的着床率分别为：50.91%、41.32%、21.35%、23.4%（P〈0.05）,妊娠率分别为64.15%、62.82%、40.54%、45.0%（P〈0.05）,均呈一定的下降趋势。而各组间的流产率无显著差异（P〉0.05）。结论：随着年龄的增长,正常形态精子比率及IVF的受精率、胚胎着床率及妊娠率呈现下降的趋势,但仍需进一步的研究。Objectives： To study the relationship between paternal age and clinical outcomes of IVF- ET.Method： According to paternal age,188 couples undergoing IVF- ET were divided into 4 groups： 31 yr（ n = 53）group,31 ~ 35 yr（ n = 78） group,36 ~ 40 yr（ n = 37） group and 〉40 yr（ n = 20） group. The relationship between paternal age and clinical outcomes of IVF- ET were analyzed. Results： In this study,there was no significant difference among the four groups in maternal age,infertility duration,endometrial thickness,base FSH level,Gn dosage,number of oocytes retrieved,number of MII oocytes,the rates of useful embryos and good quality embryos（ P〉0. 05）. And there was no significant difference among the four groups in semen volume,sperm concentration and rate of progressive sperm. However,the rate of morphologically normal sperm in 36 ~ 40 yr group（ 9. 3 ± 3. 0）and 〉40 yr group（ 9. 5 ± 2. 6） were both significantly lower than that of 〈31 yr group（ 13. 5 ± 2. 8） and 31 ~ 35 yr group（ 12. 6 ± 2. 7）（ P〈0. 05）. The fertilization rate of 36 ~ 40 yr group（ 76. 6%） was significantly lower than that of 〈31 yr group（ 83. 1%） and 31 ~ 35 yr group（ 81. 4%）（ P〈0. 05）. In the 〈31 yr group,31 ~ 35 yr group,36 ~ 40 yr group and 〉40 yr group,the implantation rate showed an age- dependent decrease as 50. 91%,41. 32%,21. 35%,23. 4%（ P〈0. 05）; and the pregnancy rate also showed an age- dependent decrease as 64.15%,62. 82%,40. 54%,45. 0%（ P〈0. 05）. There was no significant difference among the four groups in abortion rate. Conclusion： Male age can be associated with a decline in sperm morphology,fertilization rate,implantation rate and pregnancy rate in IVF,but further studies are still needed.

关 键 词：男性年龄 精子质量 体外受精-胚胎移植 受精率 着床率 妊娠率 

分 类 号：R711.6[医药卫生—妇产科学]