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作 者:韩荔芬[1] 赵芝萍[2] 俞晓玲[3] 丘仲琼[2] 何彩玲[2] 官升灿[1] 谢守云[1] 王玉海[1] 刘路[1] 叶寒辉[1] 潘晨[1] 李芹[1]
机构地区:[1]福州市传染病医院福建医科大学孟超肝胆医院感染科,350025 [2]福州市传染病医院福建医科大学孟超肝胆医院医院感染科,350025 [3]福州市传染病医院福建医科大学孟超肝胆医院医院药学部,350025
出 处:《中华传染病杂志》2016年第11期665-669,共5页Chinese Journal of Infectious Diseases
摘 要:目的分析5例输入性黄热病患者的流行病学特征及临床特点,探讨输入性黄热病医院感染预防控制策略和措施。方法回顾性研究2016年3月18日至2016年4月6日,福州市传染病医院收治的黄热病确诊患者5例的流行病学及临床资料,并进行分析。结果5例患者均来自安哥拉罗安达省,1例患者于出国前接种过黄热病疫苗,其余患者出国前均未接种过疫苗,仅在发病前1~10d接种了黄热病疫苗。所有患者发病前均有蚊虫叮咬史。发病时间集中于2016年3月10日至3月18日,所有病例均在回国前发病。归国时间为2016年3月11日至3月27日。临床表现主要包括发热、畏冷、寒战、乏力、全身关节酸痛、头痛、肝脏损害、肾脏损害等。2例患者人院时血清黄热病毒核酸仍阳性,3例患者仅尿液黄热病毒核酸阳性。所有患者血清登革病毒、寨卡病毒核酸及抗体均阴性,血涂片未找到疟原虫。患者均治愈好转出院,未发生死亡。结论黄热病在福建省存在传播的风险。预防控制的重点在于提高输入性病例的发现和应对能力;对前往疫情流行国家/地区的人员开展免疫预防和卫生知识宣教;开展蚊媒的应急监测和控制。Objective To analyze the epidemiologicaf and cfinicaf cfiaracteristics of 5 b-patients with importing yellow fever, and to explore the preventive and control strategies of infection in hospital. Methods The epidemiologieal and clinical characteristics of 5 cases of importing yellow fever in Infectious Disease Hospital of Fujian Medical University from March 18th to April 6th in 2016 were retrospectively reviewed and analyzed. Results Five patients were all from Angola Luanda. One of them was vaccinated before going aboard, and the others were vaccinated 1--10 days before disease onset in Angola. All of them were bitten by mosquitoes, and their onset date ranged from March 11th to March 27tb, before returned to Fujian. The main clinical symptoms were fever, chilly, shivering, fatigue, arthrodynia, headache, and liver and kidney injury. At manifestations, two patients had positive nuclear acid of yellow fever virus in serum samples and 3 patients were positive in urine samples. All of these patients were negative for dengue virus and Zika virus testing, meanwhile no plasmodium was found in blood smears. All patients were cured and discharged. Conclusions There is risk of yellow fever transmission in Fujian Province.Prevention and control of the disease should be focus on improving the ability of finding and coping with the importing cases. Vaccination and hygiene knowledge propagation should be given for those who are going to epidemic country/area. Emergency monitoring and control of mosquitoes are necessary.
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