胰十二指肠同源异型盒基因-1多态性与2型糖尿病的相关性  

Association between polymorphism of PDX-1 gene and type 2 diabetes mellitus

作　　者：谭英姿[1] 李俊燕[1] 陶枫[1] 陆灏[1] TAN Ying-Zi LI Jun-Yan TAO Feng et al.(Diabetes Research Institute, Department of Endocrinology, Shanghai Key Laboratory of Traditional Chinese Clinical Medice, Shu- guang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China)

机构地区：[1]上海中医药大学附属曙光医院内分泌科糖尿病研究所中医临床重点实验室,上海201203

出　　处：《中国老年学杂志》2016年第24期6136-6138,共3页Chinese Journal of Gerontology

基　　金：国家自然科学基金(No.81403359);上海市中医临床重点实验室(No.14DZ2273200);上海市中医药事业发展三年行动计划项目(No.ZYSNXD-CC-YJXYY)

摘　　要：目的探讨胰十二指肠同源异型盒基因(PDX)-1多态性位点(rs4415872,rs1124607和rs4581569)与上海汉族人群2型糖尿病的关系。方法选取1 285例正常健康个体为对照组,经确诊的1 245例2型糖尿病患者为病例组。收集静脉血液标本1 ml,提取全基因组DNA。应用Taqman基因分型技术进行多态性检测。结果与对照组相比,PDX-1基因rs1124607位点的基因型和等位基因频率分布在病例组中具有统计学意义[基因型:P=7.82×10^(-5);等位基因:P=0.000 9,OR=0.780(0.688~0.886)]经Bonferroni矫正后仍具有统计学差异(基因型:P=2.35×10^(-4);等位基因:P=0.000 3)。结论 PDX1基因rs1124607位点可能与上海汉族人群2型糖尿病具有相关性。Objective To study the association of pancreatic and duodenal homeobox 1 （PDX-1） polymorphism （rs4415872, rs1124607 and rs4581569） with type 2 diabetes mellitus（T2DM） in Han population of Shanghai. Methods 1 245 cases of T2DM patients were recruited as case and 1 285 healthy individuals were selected as control. 1 ml of blood sample was collected from each subject, from which the whole genomic DNA was extracted. The polymorphism was detected by Taqman technology. Results Significant association was observed in PDX-1 rs1124607 genotypes and alleles with T2DM [P=7.82×10^5 and P=0.000 1,OR=0. 78（0.68 -0.87） ,respectively]. After Bonferroni correction,significant association was still detected. Conclusions The polymorphism of rs1124607 in PDX-1 gene may be associated with T2DM in Hart population from Shanghai region.

关 键 词：2型糖尿病 基因多态性 胰十二指肠同源异型盒基因 

分 类 号：R587[医药卫生—内分泌]