载脂蛋白A-I模拟肽的研究进展  

Research advances on the apolipoptrotein A-I mimetic peptides

作　　者：刘湘[1,2,3] 欧志君[4,3] 李艳[1,2,3] 区景松[1,2,3,5] LIU Xiang OU Zhi-jun LI Yan OU Jing-song(Division of Cardiac Surgery, The First Affiliated Hospital of Sun Yat - sen University, Guangzhou 510080, China The key Laboratory of Assisted Circulation, Ministry of Health, Zhongshan School of Medicine, SYSU, Guangzhou 510275, China Division of Hypertension and Vascular Diseases, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China National and Guangdong Province Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, Guangzhou 510080, China Guangdong Provincial Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine of Sun Yat-sent University, Guangzhou 510080, China)

机构地区：[1]中山大学附属第一医院心脏外科,广东广州510080 [2]中山大学中山医学院卫生部辅助循环重点实验室,广东广州510275 [3]中山大学附属第一医院血管疾病诊治国家地方联合工程实验室,广东广州510080 [4]中山大学附属第一医院高血压血管病科,广东广州510080 [5]广东省脑功能与脑疾病重点实验室,广东广州510080

出　　处：《中国生化药物杂志》2016年第12期20-24,共5页Chinese Journal of Biochemical Pharmaceutics

基　　金：教育部长江学者奖励计划项目;国家杰出青年科学基金(81325001);国家自然科学基金(81170271;81370370);广东省高等学校高层次人才项目(珠江学者计划);国家临床重点专科建设项目;科技部国际合作专项(2015DFA31070);广东省自然科学基金研究团队项目(2015A030312009)

摘　　要：高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)由于其心血管保护作用而受到广泛的关注。研究发现,正常HDL在机体内起着逆转运胆固醇、抗炎、抗氧化和促进血管新生等保护心血管的功能。作为HDL含量最高的蛋白质,载脂蛋白A-I(apolipoptrotein A-I,apo A-I)在HDL的各种功能活动中起关键作用。根据apo A-I的两亲性α-螺旋结构特点,设计了一系列旨在模拟apo A-I功能的模拟肽。Apo A-I模拟肽的功能和代谢取决于它的氨基酸组成和序列,并被证实在心血管疾病、感染、炎症和氧化损伤、代谢综合征和肿瘤等疾病状态下发挥保护作用。部分临床试验肯定了apo A-I模拟肽的效益,但由于其高昂的成本而限制了它的实际应用。High density lipoprotein cholesterol（ HDL-C） has received extensive attention because of its cardiovascular protective effects. Recent studies showed that HDL could promote reverse cholesterol transport（ RCT）, be anti-inflammatory and antioxidant, and induce angiogenesis.Apolipoptrotein A-I（ apo A-I）,the most abundant protein of HDL,plays a pivotal role in the HDL mediated-functional activities. Short peptides based on the amphiphilic alpha helix structure of apo A-I have been designed and aimed at imitating the function of apo A-I. The function and metabolism of these mimetic peptides depend on their amino acids component and sequence,and have been proved to exert protection in against cardiovascular disease,infection,inflammation and oxidative damage,metabolic syndrome and tumor. Clinical trials confirmed their benefits,but high cost put them out of the practical applications..

关 键 词：载脂蛋白A-I 心血管疾病 炎症 代谢综合征 

分 类 号：R541.4[医药卫生—心血管疾病]