冠心病患者血清中血管内皮细胞生长因子与超敏C反应蛋白变化  

Changes of serum VEGF and hs-CRP levels in coronary heart disease

作　　者：董政[1] 孙黎明[1] 王怡练[1] 徐海涛[1] 王罗卿[1] DONG Zheng SUN Li-ming WANG Yi-lian XU Hai-tao WANG Luo-qing(Department of Cardiology, The Second People＇s Hospital of Lianyungang, Lianyungang 222006, Chin)

机构地区：[1]江苏省连云港市第二人民医院心内科,江苏连云港222006

出　　处：《中国生化药物杂志》2016年第12期177-179,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的调查冠心病患者血清中血管内皮细胞生长因子（vascular endothelial growth factor,VEGF）与超敏C反应蛋白（high-sensitivity C-reactive protein,hs-CRP）的变化,进一步探索其临床意义。方法选取2015年1月~2016年2月来江苏省连云港市第二人民医院心内科接受治疗的90例冠心病患者作为观察组,以同期在本院进行体检的30例健康个体作为对照组,观察组分为稳定型心绞痛（stable angina pectoris,SAP）,心肌梗死（acute myocardial infarction,AMI）和不稳定型心绞痛（unstable angina pectoris,UAP）亚组。采用ELISA法检测所有研究对象的血清VEGF和hs-CRP浓度。结果观察组患者的血清VEGF和hs-CRP浓度显著高于对照组,差异有统计学意义（P〈0.05）,观察组内3组患者两两比较时发现AMI组患者的血清VEGF和hs-CRP浓度显著高于SAP、UAP组,UAP组患者血清VEGF和hs-CRP浓度高于SAP组（P〈0.05）;冠心病患者的VEGF和hs-CRP浓度呈显著正相关（r=0.626,P〈0.05）;ROC则表明两指标对冠心病均具有较高的诊断价值。结论冠心病患者的血清VEGF和hs-CRP浓度的变化对冠心病的诊断价值和准确度比较高,可以作为评估冠心病患者病情变化及预测心血管事件事件发生与发展的指标。Objective To explore the changes of vascular endothelial growth factor（ VEGF） and high-sensitivity C-reactive protein（ hs-CRP）levels in the patients with coronary heart disease（ CHD）,and its clinical significance. Methods Nighty cases with CHD in our hospital from January2015 to February 2016 were selected as study group,while 30 cases healthy persons underwent physical examination were selected as control group,and the study group were divided into stable angina pectoris（ SAP） group,acute myocardial infarction（ AMI） group and unstable angina pectoris（ UAP）group. The serum VEGF and hs-CRP levels were detected by ELISA. Results The serum VEGF and hs-CRP levels in study group were higher than those in control group（ P〈0. 05）. The serum VEGF and hs-CRP levels in AMI group were higher than those in SAP group and UAP group,the serum VEGF and hs-CRP levels in UAP group were higher than SAP group（ P〈0. 05）. There was positive correlation between serum level of VEGF and hs-CRP（ r =0. 626,P〈0. 05）. The ROC showed a higher diagnostic value of VEGF and hs-CRP on CHD. Conclusion The serum levels of VEGF and hs-CRP has a higher diagnostic value and accuracy on CHD,which could evaluate the patient＇s condition and predict the progress of cardiovascular events.

关 键 词：冠心病 内皮细胞生长因子 超敏C反应蛋白 预测 

分 类 号：R541.4[医药卫生—心血管疾病]