甲磺酸法舒地尔治疗急性脑梗死的疗效和安全性  

Mesylate Fasudil Treatment of Acute Cerebral Infarction and Safety

作　　者：谢春香[1] 

机构地区：[1]吉林医药学院附属医院神经内科,吉林吉林132013

出　　处：《中外医疗》2016年第34期110-111,114,共3页China & Foreign Medical Treatment

摘　　要：目的研究分析甲磺酸法舒地尔治疗急性脑梗死的临床疗效及其安全性。方法按照随机数字表法将方便选取的该院神经内科2014年6月—2016年6月收治的78例急性脑梗死患者分为两组,观察组39例患者采用甲磺酸法舒地尔治疗,对照组39例患者采用常规治疗,并对比其血清因子水平及临床疗效。结果两组患者治疗前的Hcy、CRP等因子水平相比,其差异无统计学意义(P>0.05),治疗后观察组患者的Hcy为(8.58±1.22)mol/L,CRP为(9.56±3.42)mg/L,低于对照组患者的(18.01±2.11)mol/L、(14.32±4.51)mg/L,组间差异有统计学意义(P<0.05)。观察组患者经一个月治疗后临床总有效率为94.87%,对照组患者的临床总有效率为79.49%,两组相比其差异有统计学意义(P<0.05)。结论急性脑梗死患者应用甲磺酸法舒地尔药物治疗具有显著临床疗效,能够降低患者Hcy、CRP水平,改善脑水肿、神经功能缺损,促进机体早日康复,值得临床应用。Objective To analyze mesylate fasudil treatment of acute cerebral infarction clinical efficacy and safety. Methods Convenient selection 78 patients with acute cerebral infarction in a random number table of Neurology in our hospital in June 2014 to June 2016 admitted into 2 groups, 39 cases were treated with methane sulfonic acid fasudil treatment, control 39 patients were treated with conventional therapy, and serum levels of cytokines and clinical efficacy comparison. Results Hcy two groups of patients before treatment, CRP levels and other factors compared to the difference was not statistically significant（P〈0.05）, after treatment of patients with Hcy observation group was（8.58 ± 1.22） mol / L, CRP is（9.56 ±3.42） mg / L, lower than the control group of patients（18.01 ± 2.11） mol / L,（14.32 ± 4.51） mg / L, and the presence of inter-group difference was statistically significant（P〈0.05）. Observation group patients after one month clinical total effective rate was 94.87%, the control group of patients with clinical total effective rate was 79.49%, the two groups was statistically significant compared to their differences（P〈0.05）. Conclusion Patients with acute cerebral infarction application mesylate fasudil medications have significant clinical effect, can be reduced in patients with Hcy, CRP levels, improve cerebral edema, neurological deficits, promote the body a speedy recovery, worthy of clinical application.

关 键 词：甲磺酸法舒地尔 急性脑梗死 安全性 

分 类 号：R5[医药卫生—内科学]