小剂量5-氟尿嘧啶联合曲安奈德治疗瘢痕疙瘩的临床效果  

Clinical efficacy of low dose 5-fluorouracil with triamcinolone for treatment of keloids

作　　者：孙岩伟[1] 李亮[1] 王宁[1] 吴丹[1] 张郑[1] 

机构地区：[1]山东省淄博市中心医院烧伤整形外科,255036

出　　处：《中华医学美学美容杂志》2016年第6期352-354,共3页Chinese Journal of Medical Aesthetics and Cosmetology

摘　　要：目的评价小剂量5-氟尿嘧啶联合曲安奈德治疗瘢痕疙瘩与曲安奈德单独注射治疗瘢痕疙瘩的临床效果。方法将45例（56处）瘢痕疙瘩患者完全随机分为两组。A组采用小剂量5-氟尿嘧啶联合曲安奈德瘢痕疙瘩内注射治疗，B组采用曲安奈德单独注射治疗。采用优良、显效及无效标准评价治疗效果，优良率、显效率之和计算为有效率，并进行统计学分析。结果A组（共27处瘢痕疙瘩）：优良16处（59．3％），显效9处（33．3％），无效2处（7．4％），有效率92．6％；B组（共29处瘢痕疙瘩）：优良9处（31。0％），显效12处（41.4％），无效8处（27．6％），有效率72．4％。A组优良率及有效率较B组明显提高，差异有统计学意义（P〈0．05）。A组患者1例复发，复发率为3．7％，B组患者7例复发，复发率为24．1％，两组复发率比较差异有统计学意义（P〈0．05）。结论小剂量5-氟尿嘧啶联合曲安奈德注射治疗瘢痕疙瘩较曲安奈德单独注射治疗瘢痕疙瘩的有效率及优良率明显提高，复发率明显降低。Objective To evaluate the efficacy of low dose 5-fluorouracil （5-Fu） combined with triamcinolone in the treatment of keloids, comparing with results with use of triamcinolone treatment alone. Methods Patient records from 2012 to 2013 were reviewed. 45 patients （56 keloids） were completely randomized into 2 groups. Low dose of 5-Fu combined with triamcinolone were used to treat keloids in group A, while triamcinolone alone was used in group B. The therapeutic effects were evaluated by the certification of excellent remission, remission, inefficacy and total efficacy. The resuits were analyzed with statistics. Results In group A （27 keloids）, the excellent remission cases were 16 （59.3%）, the remission cases were 9 （33.3%）, and the inefficacy cases were 2 （7.4%）. The total percentage of efficacy in group A was 92.6%. In group B （29 keloids）, the excellent remission cases were 9 （31.0%）, the remission cases were 12 （41.4%）, and the inefficacy cases were 8 （27.6%）. The total therapy efficacy percentage of group B was 72.4%. Both the total percentage of efficacy and the excellent remission percentage in group A were apparently higher than those of group B, and the differences between the two groups were of statistical significance （P〈0.05）. The recurrence rates of group A were 3.7% （one case） while that of group B were 24.1% （7 cases）. The differences between the two groups were also of statistical significance （P〈0.05）. Conclusions Low dose 5-Fu combined with triamcinolone is superior to intralesional triamcinolone therapy alone in the treatment of keloids.

关 键 词：瘢痕疙瘩 5-氟尿嘧啶 曲安奈德 

分 类 号：R622[医药卫生—整形外科]