抗菌肽抑制脂多糖诱导的炎症反应  

Inhibitory Effects of Antimicrobial Peptides on Lipopolysaccharide-Induced Inflammation

作　　者：杨颜铱 陈芸[1] 高爽[1] 刘旗[1] 陈憧[1] 姚淑华[1] 邓俊良[1] 

机构地区：[1]四川农业大学动物医学院,动物疫病与人类健康四川省重点实验室,环境公害与动物疾病四川省高校重点实验室,成都611130

出　　处：《动物营养学报》2016年第12期3770-3776,共7页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：教育部“长江学者和创新团队发展计划”创新团队项目(IRTO848);四川农业大学双支计划(03571537)

摘　　要：抗菌肽是一种对多重耐药菌株表现出特异性抗菌机制的小分子多肽。同时,抗菌肽还具有抗炎活性,可以通过直接中和脂多糖(LPS)、抑制生物性炎症因子的产生来减轻炎症反应;亦可通过趋化白细胞、促进免疫细胞增殖等来影响获得性免疫,从而调节宿主免疫系统发挥保护作用。本文综述了近年来LPS诱导炎症产生的机制及抗菌肽抑制LPS诱导炎症反应的作用机理。Antimicrobial peptides（AMPs） are a kind of small molecular polypeptide which show the specific antibacterial mechanism to multiple drug-resistant strains.In addition,with anti-inflammatory activity,AMPs relieve inflammation by directly neutralizing lipopolysaccharide（LPS） and inhibiting the release of biological inflammatory factors.Meanwhile,they also affect the acquired immunity through the chemotaxis of leukocytes and promoting the proliferation of the immune cells to adjust the host immune system and play a protective role.This essay summarized the mechanism of LPS induced inflammation and the AMPs to inhibit LPS induced inflammation in recent years.

关 键 词：抗菌肽 脂多糖 炎症因子 抑制炎症机理 

分 类 号：S811[农业科学—畜牧学]