613例泮托拉唑不良反应报告分析  

Analysis of 613 Cases of Adverse Reaction Reports of Pantoprazole

作　　者：刘璇[1] 邓丽[1] 刘东[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院药学部,武汉430030

出　　处：《药物流行病学杂志》2016年第12期791-794,共4页Chinese Journal of Pharmacoepidemiology

摘　　要：目的：探讨泮托拉唑不良反应的规律及特点。方法：采用回顾性研究的方法,对2012-2014年湖北省不良反应监测中心数据库收集到的613例泮托拉唑不良反应报告,从年龄、性别、给药途径、给药剂量、溶媒、药品不良反应（ADR）发生时间和ADR累及器官等方面进行分类统计分析。结果：泮托拉唑使用导致的不良反应,男女比例为1.11：1,未见明显性别差异,且在各个年龄段均有分布;其中严重不良反应10例,占比为1.63%,新的不良反应18例,占比为2.94%;不良反应累及器官以中枢及外周神经系统损害（23.16%）、胃肠系统损害（23.98%）、皮肤及附件损害（18.53%）为主;严重不良反应主要为过敏性休克、心悸、严重四肢麻痹;少量病例存在溶媒选择不合理的情况。结论：加强药品不良反应的监测,完善药物使用说明书,规范使用流程,以减少泮托拉唑不良反应的发生。Objective： To explore the regularity and characteristics of adverse drug reaction（ ADR） induced by pantoprazole. Methods： Using retrospective study method,613 cases of ADR related to the pantoprazole from January 2012 to December 2014 in Hubei province were chosen,the age,sex,drug delivery,drug dosage,solvent,ADR occurrence time and ADR involving organs,etc were classified statistical analyzed. Results： The ADRs occurred in all ages,male female ratio was 1. 11 ∶ 1,there were no gender differences. There were 10 serious ADR cases,accounting for 1. 63%,the new ADR in 18 cases,accounting for 2. 94%; The main ADR damages involved nervous system damage（ 23. 16%）,gastrointestinal system damage（ 23. 98%）,skin and its appendages（ 18. 53%）,and the serious adverse reactions was allergic shock,palpitation and severe quadriplegia. There was improper solvent in several cases. Conclusion： Importance should be attached to the monitoring of ADRs and the perfecting of drug instructions in order to standardize the rational use of pantoprazoles and reduce the occurrence of adverse drug reactions.

关 键 词：泮托拉唑 药品不良反应 安全用药 

分 类 号：R975.2[医药卫生—药品]