(1R,2S)-2-氟代环丙胺对甲基苯磺酸盐的合成工艺研究  

Study on synthesis process of(1R,2S)- 2-fluorocyclopropanamine p-toluenesulfonate

作　　者：李学敏[1] 

机构地区：[1]沈阳化工研究院有限公司化工新材料所,辽宁沈阳110021

出　　处：《化学工程师》2016年第12期79-82,共4页Chemical Engineer

摘　　要：本文旨在提供一种西他沙星关键中间体的制备方法,其合成路线为:以烯丙基溴为原料,经苄基保护、加成、脱保护、氧化、脱氯、异构体分离、酰氯化、重排得到关键中间体(1R,2S)-2-氟代环丙胺对甲基苯磺酸盐。此工艺具有收率高、操作简便、原料易得、适合工业化生产等优点。The aim of this paper is to provide one method for the preparation of the key intermediate of sitafloxacin, The synthetic route is： with allyl bromide as raw materials by benzyl protection,addition reaction,de- protection,oxidation, dechlorination, isomer separation, acylation and rearrangement prepare of the key intermediate（ 1R, 2S） -2-fluorocyclopropanamine p-toluenesulfonate. This process has the advantages of high yield, simple operation, easy to get raw materials, suitable for industrial production, etc.

关 键 词：西他沙星 2-氟代环丙胺对甲基苯磺酸盐 合成 

分 类 号：TQ073[化学工程]