含对乙酰氨基酚药物的不良反应与合理使用  

Adverse reactions and rational use of acetaminophen containing drugs

作　　者：丁召兴[1] 成文娜[1] 高菲[1] 徐洋洋[1] 丁长玲[1] DING Zhaoxing CHENG Wenna GAO Fei XU Yangyang DING Changling(Affiliated Hospital of Binzhou Medical College, Binzhou 256603, Chin)

机构地区：[1]滨州医学院附属医院,山东滨州256603

出　　处：《药学研究》2016年第12期737-741,共5页Journal of Pharmaceutical Research

基　　金：山东省医药卫生科技计划课题(No.2014WS0488);滨州市软科学研究计划项目(No.2014BK22);滨州医学院科技计划课题(No.BY2013KJ12)

摘　　要：目的了解含对乙酰氨基酚药物的不良反应和临床应用情况,提高临床用药合理性。方法通过总结含对乙酰氨基酚药物及其含量,结合我院近5年发生的27例含对乙酰氨基酚药物致不良反应患者,对其临床资料进行回顾性分析,探讨不良反应发生类型和影响因素以及临床不合理应用情况。结果含对乙酰氨基酚药物有69种,主要不良反应涉及消化系统、呼吸系统、泌尿系统、血液系统、过敏反应等;临床上同时应用含对乙酰氨基酚的感冒药情况较常见。从我院收集的27例不良反应中,严重不良反应所占比例较高,占88.89%;原患疾病以上呼吸道感染例数较多,有16例,占59.26%。结论含对乙酰氨基酚药物种类繁多,不良反应严重,肝损害较明显;临床应用存在用量过大、重复用药、服药期间饮酒等问题,给患者用药安全带来很大风险,需引起高度重视,加大宣传和培训力度,最大限度减少药物损害事件发生。Objective To explore the adverse reactions and clinical applications induced by acetaminophen drugs to improve the rationality of clinical drug use.Methods 27 cases of adverse drug reactions induced by acetaminophen in our hospital during the past 5 years, the clinical data were retrospectively analyzed to investigate the types of adverse reaction and influence factors and clinical irrational application by summarizing the content of acetaminophen drugs and their content.Results 69 kinds of drug containing acetaminophen, the main adverse reactions involved in the digestive system, respiratory system, urinary system, blood system, allergic reaction, etc. Clinical application of cold medicine containing acetaminophen was more common.Serious adverse reactions accounted for a higher proportion in 27 cases of adverse reactions collected from our hospital, accounting for 88.89% ; There were more cases of respiratory tract infection, 16 cases, accounting for 59.26%.Conclusion With a wide range of acetaminophen drugs, clinical irrational use of the phenomenon should be caused by a high degree of attention,increasing publicity and training efforts to minimize the occurrence of drug damage.

关 键 词：对乙酰氨基酚 不良反应 合理用药 复方制剂 

分 类 号：R971.1[医药卫生—药品]