HBV-DNA定量在慢性乙肝阳性未治疗孕妇妊娠期间的变化意义  

Signifi cance of HBV-DNA quantitative changes in the treatment of chronic hepatitis B positive without treatment of pregnant women during pregnancy

作　　者：倪霜玲[1] NI Shuang-ling.(Zhejiang Lishui People＇ s Hospital, Dept. Of lnfection, 32300)

机构地区：[1]浙江省丽水市人民医院感染科,浙江丽水323000

出　　处：《中国优生与遗传杂志》2016年第12期89-91,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探究未治疗的慢性乙肝阳性孕妇在妊娠不同时期血清HBV-DNA定量变化及与肝功能指标的联系。方法选取在我院进行全程产检并确诊为慢性乙肝阳性的35例孕妇为观察组,并选取同时期进行孕期检查未查出有乙型肝炎的36例孕妇作为对照组。比两组孕妇在不同孕期时血清肝功能指标水平差异;比较不同孕期观察组研究对象HBV-DNA及乙肝标志物定量变化;分析不同孕期观察组孕妇HBV-DNA定量与相关肝功能指标的联系。结果观察组孕妇在不同孕期血清肝功能检测指标中ALT、GGT水平较对照组明显增加,且随孕期的发展而不断上升;观察组孕妇随着孕期的发展,HBV-DNA定量值也在逐渐增加,乙肝标志物HBs Ag、HBe Ag定量变化不大无意义;根据Pearson检验分析不同孕期观察组血清HBV-DNA定量与肝功能指标ALT、GGT的相关性得出,观察组各孕期血清HBV-DNA定量与ALT、GGT无明显相关性。结论不接受治疗的乙肝HBVDNA阳性孕妇随着孕期的发展,HBV-DNA定量虽呈逐渐上升趋势,但不能作为评价肝功能损伤程度的指标,需增加此类孕妇肝功能及随访观察,注意其病情变化和风险评估。Objective：To explore the quantitative changes of serum HBV-DNA levels in patients with chronic hepatitis B and their relationship with liver function indexes in different periods of pregnancy. Methods：35 cases of pregnant women who were diagnosed as chronic hepatitis B were selected in our hospital as the observation group,and 36 pregnant women with hepatitis B were selected as control group. Than the two groups of pregnant women in different pregnancy serum liver function indicators of the level of difference;comparison of different pregnancy observed groups of HBV-DNA and HBV markers quantitative changes;analysis of different pregnancy group of pregnant women HBV-DNA and liver function were observed. Results：Observation group of pregnant women in different gestational serum liver function indexes in alt,GGT level was significantly higher than that in the control group and with the development of pregnancy and rising;pregnant women group with the development of pregnancy,HBV-DNA quantitative value also in gradually increased,HBV markers HBs Ag and HBe Ag quantitative change is not without significance;according to the Pearson correlation analysis in different periods of pregnancy group serum HBV-DNA quantitative and index of liver function alt,GGT correlation observed that observed group each pregnancy serum HBV-DNA quantitative and alt,GGT no significant correlation is observed. Conclusions：Do not accept treatment of HBV-DNA positive hepatitis B pregnant women with the development of pregnancy,HBV-DNA was gradually rising trend,not as an index of evaluating liver function damage degree,strengthen the liver cell injury and follow-up observation,but HBV-DNA quantitative changes for antiviral therapy and prognosis still important reference value. Because of the limited sample size in this paper,the conclusions still need to be further studied.

关 键 词：慢性乙肝阳性 孕妇 肝功能 HBV-DNA 

分 类 号：R714.251[医药卫生—妇产科学]