机械力诱导氧化应激中Nrf2抗氧化机制的相关研究  

Research Progress on Antioxidant Mechanisms of Nrf2 in Oxidative Stress Induced by Mechanical Forces

作　　者：方桂[1] 洪莉[1] 李秉枢[1] 刘成[1] 石华[1] 吴文英[1] FANG Gui HONG Li LI Bingshu LIU Cheng SHI Hua WU Wenying(Dept. of Obstetrics and Gynecology Ultrasound, Renmin Hospital of Wuhan University, Wuhan 430060, Chin)

机构地区：[1]武汉大学人民医院妇产超声科,湖北武汉430060

出　　处：《武汉大学学报（医学版）》2017年第1期165-168,172,共5页Medical Journal of Wuhan University

基　　金：国家自然科学基金资助项目(编号:81270684);武汉大学医学部协同创新项目(编号:523-266078)

摘　　要：Nrf2是细胞抗氧化反应的中枢调节者,通过与Keap1、ARE等相互作用启动抗氧化基因及Ⅱ相解毒酶的基因转录,调节许多细胞保护蛋白质的表达,保护细胞免受氧化应激损伤。氧化应激是力学相关性疾病引起细胞损伤的重要机制,Nrf2抗氧化机制在力学相关性疾病中的作用日益受到重视。本文在Nrf2的结构、调控机制及其在机械力学中的作用机制进行综述,探讨其在力学相关性疾病的预防和治疗中的作用。Nrf2is a central regulator in the cellular antioxidant response,which starts the gene transcription of antioxidant gene and phageⅡdetoxification enzymes,then regulates the expression of much cell protective proteins,thus protect cell against oxidative stress injures.Oxidative stress is an important mechanism causing cell damage induced by mechanical force,and the antioxidant mechanism of Nrf2 in mechanical related disease received increasing attention now.So in this paper,we review the structure,regulating mechanism,and the role in mechanical related disease of Nrf2,and investigate its role in the prevention and treatment of mechanical related disease.

关 键 词：NRF2 氧化应激 机械力 

分 类 号：R34[医药卫生—基础医学]