神经生长因子联合碱性成纤维细胞成长因子治疗压力性溃疡  

Nerve Growth Factor Combined with Basic Fibroblast Growth Factor for Pressure Ulcer

作　　者：冯琼[1] 吴庆[2] 钟清玲[1] 贾书磊[1] 刘萌[1] 周彩云[1] 

机构地区：[1]南昌大学护理学院,南昌330006 [2]南昌大学第二附属医院骨科,南昌330006

出　　处：《南昌大学学报（医学版）》2016年第5期30-32,39,共4页Journal of Nanchang University：Medical Sciences

摘　　要：目的探讨碱性成纤维细胞成长因子和神经生长因子联合局部治疗压力性溃疡效果。方法建立SD大鼠压力性溃疡(Pressure Ulcer,PU)模型,实验分为对照组(A组),使用bFGF治疗;实验组(B组)以bFGF与NGF联合治疗。结果分别于造模后第1、2、3、4、5、6天对溃疡局部的NGF质量浓度及创面愈合率进行比较,B组的NGF质量的浓度均高于A组(P<0.01);B组愈合率在各个时间点均显著高于A组(P<0.01)。各组未出现感染等并发症。结论 bFGF与NGF联合治疗压力性溃疡的效果优于单独使用bFGF。Objective To investigate the effect of local treatment with combined basic fibroblast growth factor（bFGF） and nerve growth factor（NGF） on pressure ulcer（PU）. Methods The PU was induced in rats. Then, PU rats were treated with bFGF alone（group A） or in combination with NGF （group 13）. Results Compared with group A, NGF concentrations increased and PU healing rates decreased in group B on days 1,2, 3,4, 5 and 6 after model establishment （P〈0.01）. No infection and other complications occurred in both groups. Conclusion The combination of bFGF and NGF is superior to bFGF alone for treating PU.

关 键 词：压力性溃疡 碱性成纤维细胞成长因子 神经生长因子 联合治疗 

分 类 号：R3-22[医药卫生—基础医学]