反相乳液法制备海藻酸钠/壳聚糖纳米微球  

Preparation of sodium alginate/chitosan nanosphere in reverse emulsion

作　　者：李凤红[1] 相丽英 宣天义 陈旭[1] 张萌[1] 汪维波[1] 徐洪营 万佳康 Li Fenghong Xiang Liying Xuan Tianyi Chen Xu Zhang Meng Wang Weibo Xu Hongying Wan Jiakang(School of Petrochemical Engineering, Shenyang University of Technology, Liaoyang 111003 Yifang Industrial Company, Petrochina Liaoyang Petroleum Chemical Fiber Co. , Ltd. Liaoyang 111003)

机构地区：[1]沈阳工业大学石油化工学院,辽阳111003 [2]辽阳石油化纤公司亿方工业公司,辽阳111003

出　　处：《化工新型材料》2016年第12期106-108,共3页New Chemical Materials

基　　金：辽宁省自然科学基金资助项目(20102172);沈阳工业大学博士启动基金(201130);2015辽宁省大学生创新创业计划项目(201566);2016国家级大学生创新创业计划项目(201591)

摘　　要：分别以吐温80和复合乳化剂司盘80/吐温80为乳化剂,采用反相乳液法,以大豆油为油相,氯化钙（CaCl2）为交联剂制得海藻酸钠（ALG）/壳聚糖（CS）纳米微球。采用SEM和激光粒度分析仪对纳米微球的形貌和粒径进行表征。结果表明,采用复合乳化剂司盘80/吐温80适合油包水体系,制得的ALG/CS纳米微球粒子为球形;采用复合乳化剂比采用单一乳化剂制备的纳米微球粒径分散指数小;随着司盘80∶吐温80的质量配合比不同,微球的粒径随复合乳化剂中吐温80量的增加而减少,粒径分散指数PDI值在0.1~0.2之间;当司盘80∶吐温80质量配合比为1∶1.4时,制得的纳米微球平均粒径最小为364.4nm;当司盘80∶吐温80质量配合比为1∶0.2时,制得的纳米微球平均粒径最大为1171nm。The sodium alginate/chitosan nanospheres were prepared with soybean oil as oil phase using the method of reverse emulsion. The emulsifier of Tween80 and compound emulsifier of Span80/Tween80 were used, respectively, and calci- um chloride was used as crosslinking agent. The morphology and particle size of nanoparticles were characterized by scanning electron microscopy （SEM） and dynamic light scattering （DLS）. The results indicated that the compound emulsifier of Span80/Tween80 was suitable for water-in-oil system. The shape of Alginate/CS nanoparticles was spherical. The particle size polydispersity index （PDD of microsphere with compound emulsifier was smaller than using a single emulsifier. For the differ- ent ratio of Span80/Tween80 compound emulsifier, the diameter of nanomicrosphere reduced with increasing the amount of Tween80. The values of PDI was between 0. 1 to 0.2. The minimum average particle size of nanospheres was 364.4nm as the mass ratio of Span80/Tween 80 was 1 ： 1.4. When the mass ratio of Span80/Tween80 was 1 ： 0.2, the resulting average particle size of nanosphere was up to 1171 nm.

关 键 词：海藻酸钠 壳聚糖 反相乳液 纳米微球 制备 

分 类 号：TB383.1[一般工业技术—材料科学与工程]