母血浆中胎儿游离核酸与无创性产前亲子鉴定  

Cell-free fetal nucleic acid in maternal plasma and noninvasive prenatal paternity testing

作　　者：余谨[1,2] 肖超[1] 黄代新[1] Yu Jin Xiao Chao Huang Daixin(Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Wuhan Blood Center, Wuhan 430033, China)

机构地区：[1]华中科技大学同济医学院法医学系,湖北武汉430030 [2]武汉血液中心,湖北武汉430030

出　　处：《中国法医学杂志》2016年第6期587-590,594,共5页Chinese Journal of Forensic Medicine

基　　金：武汉市卫生和计划生育委员会科研项目(WX15D61)

摘　　要：近年来,涉及胎儿亲权鉴定的案例逐渐增多。传统胎儿产前亲权鉴定常需有创性取样,故存在一定的风险。母血浆中胎儿游离核酸的发现,给无创性产前亲权鉴定带来了新的契机。本文主要就母血浆中胎儿游离核酸及其在无创性产前亲权鉴定中的应用价值和前景进行简要介绍。In recent years, the cases of prenatal paternity testing gradually increased in forensic practice. The traditional prenatal patemity analysis can be performed only after invasive sampling of chorionic villi or amniotic fluid, which can result in a risk of miscarriage. The existence of circulating cell-free fetal nucleic acid in maternal plasma has brought new opportunities for the noninvasive prenatal paternity testing. In this paper, the research situation and application prospect of circulating cell-free fetal nucleic acid in maternal plasma in prenatal paternity testing are reviewed.

关 键 词：法医物证学 无创性产前亲子鉴定 胎儿游离核酸 差异甲基化区 

分 类 号：D919.4[医药卫生—法医学]