糖耐量正常的2型糖尿病一级亲属肠促胰岛素分泌与胰岛β细胞功能的研究  

Research on incretin secrete and islet function in first-degree relatives of Type 2 diabetes with normal glucose tolerance

作　　者：高哲[1] 卢亚敏[2] 李彩英[1] 崔秋英[3] 宋光耀[1] GAO Zhe et al(Department of internal secretion of Hebei people＇s hospital ＆ Hebei provincial internal secretion and metabolic disease institute, Shijiazhuang, Hebei, 050051, China)

机构地区：[1]河北省人民医院内分泌科,河北省内分泌代谢病研究所,河北省石家庄市050051 [2]河北省人民医院核医学科 [3]河北省人民医院检验科

出　　处：《齐齐哈尔医学院学报》2016年第28期3546-3548,共3页Journal of Qiqihar Medical University

基　　金：中华医学会临床医学科研专项资金项目(13061000485);河北省卫生计生委科研基金资助项目(20120212)

摘　　要：目的探讨年轻的糖耐量正常的2型糖尿病一级亲属肠促胰岛素分泌、胰岛β细胞功能的改变。方法正常对照组(NC)和糖耐量正常的2型糖尿病一级亲属组(FDRs)口服75克葡萄糖后0、30、60、120、180分钟抽血,分别测定血糖、胰岛素、C肽、抑胃多肽(GIP)和胰高血糖素样肽-1(GLP-1)浓度,计算各指标曲线下面积评估其分泌情况,用HOMA-IR、HOMA-β、ΔI30/ΔG30评估胰岛β细胞功能。结果(1)空腹血糖、胰岛素、C肽、GIP和GLP-1两组比较均无统计学差异(P>0.05)。(2)糖负荷后血糖、胰岛素、C肽、GIP、GLP-1曲线下面积两组比较均无统计学差异(P>0.05)。(3)HOMA-IR、HOMA-β、ΔI30/ΔG30两组比较均无统计学差异(P>0.05)。结论早期年轻的糖耐量正常2型糖尿病一级亲属肠促胰岛素分泌与胰岛β细胞功能可能尚未发生改变。Objective To investigate the changes of incretin secrete and islet function in young firstdegree relatives of type 2 diabetes with normal glucose tolerance. Methods The total subjects including 15 cases with normal glucose tolerance（ NC） and 15 first-degree relatives of type-2 diabetes with normal glucose tolerance（ FDRs） consumed the 75 g glucose orally. At 0,30,60,120 and 180 minutes following glucose,plasma concentrations of gastric inhibitory polypeptide（ GIP）, glucagon-like peptide-1（ GLP-1） and serum concentrations of glucose,c-peptide and insulin were measured. The area under curve of evaluation index was calculated,and islet beta cell function was assessed by test HOMA-IR,HOMA-β,ΔI30 / ΔG30. Results We found no significant difference in concentrations of fasting glucose,insulin,c-peptide,GIP and GLP-1 between two groups（ P〉0.05）. No significant difference was observed between two groups in the areas under the curve of glucose,insulin,c-peptide,GIP and GLP-1 after 75 g oral glucose（ P〉0. 05）. No significant difference was observed in HOMA-IR,HOMA-β,ΔI30 / ΔG30 between two groups（ P〉0. 05）. Conclusions This study demonstrates that no changes of incretin and islet function in yong first-degree relatives of type 2 diabetes with normal glucose tolerance were observed.

关 键 词：一级亲属 2型糖尿病 肠促胰岛素 胰岛功能 糖耐量 

分 类 号：R587.1[医药卫生—内分泌]