Photoredox-catalyzed amide-directed selective sp^3 C–H bond functionalization  

作　　者：Wenliang Wu Weiping Su Wenliang Wu;Weiping Su(State Key Laboratory of Structure Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences)

机构地区：[1]State Key Laboratory of Structure Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences

出　　处：《Science Bulletin》2016年第24期1892-1893,共2页科学通报（英文版）

基　　金：supported by Natural Science Foundation of Fujian Province(2013J05035)

摘　　要：Over the past century, transition metal-catalyzed crosscoupling reactions have evolved to be among the most used C-C bond forming reactions in chemical synthesis. An important remaining challenge is to synthesis with heightened levels of efficiency by new method. A powerful new class of reactions that introduce oxidized functionality directly into sp3 C-H bonds of hydrocarbons is emerging [1, 2]. Despite important advances in the aliphatic C-H bond activations, selective functionalization with complex substrates has only been demonstrated for activated C-H bonds such as location adjacent to a heteroatom or substrate with directing groups [3]. High-efficient oxidations of isolated, unactivated sp3 C-H bonds are rare. The challenge to solve this problem lies in discovering new methodology that is both highly efficient and predictably selective for oxidizing these inert C-H bonds.Over the past century,transition metal-catalyzed crosscoupling reactions have evolved to be among the most used C–C bond forming reactions in chemical synthesis.An important remaining challenge is to synthesis

关 键 词：过渡金属催化 C-H键 氧化还原 SP3 活化 定向选择 交叉偶联反应 酰胺 

分 类 号：O621.251[理学—有机化学]