Cytotoxic Effects of Rapana venosa Hemocyanin on Bladder Cancer Permanent Cell Lines  

作　　者：Arnulf Stenzl Alexander Dolashki Stefan Stevanovic Wolfgang Voelter Wilhelm Aicher PavlinaDolashka Arnulf Stenzl;Alexander Dolashki;Stefan Stevanovic;Wolfgang Voelter;Wilhelm Aicher;PavlinaDolashka(Department of Urology, University of Tiibingen Hospital Hoppe-Seyler-Strαβe 3, Tiibingen 72076, Germany;Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 9 G. Bonchev St., Sofia 1113, Bulgaria;Department of Immunology, Institute for Cell Biology, University of Tubingen, Auf der Morgenstelle 15, Tvbingen 72076,Germany;lnterfacultary Institute of Biochemistry Eberhard-Karls-University of Tuebingen, Hoppe-Steyler-Strasse 4, Tvbingen 72076,Germany)

机构地区：[1]Department of Urology, University of Tiibingen Hospital Hoppe-Seyler-Strαβe 3, Tiibingen 72076, Germany [2]Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 9 G. Bonchev St., Sofia 1113, Bulgaria [3]Department of Immunology, Institute for Cell Biology, University of Tubingen, Auf der Morgenstelle 15, Tvbingen 72076,Germany [4]lnterfacultary Institute of Biochemistry Eberhard-Karls-University of Tuebingen, Hoppe-Steyler-Strasse 4, Tvbingen 72076,Germany

出　　处：《Journal of US-China Medical Science》2016年第4期179-188,共10页美中医学（英文版）

摘　　要：The cytotoxic activities of hemocyanin from Rapana venosa and its structural subunits with different oligosaccharide structures are studied in vitro on the bladder cancer permanent cell lines CAL-29, T-24, and the normal urothelial cell line HL 10/29. A significant cytotoxic effect against these tumor cells was obserled for the functional unit RvH1-c after a treatment in contrast to native RvH and its structural subunits. Cells, treated with RvH1-c, show a mixture of both, necrotic and apoptotic cells. Cytotoxicity of RvH 1-c is probably due to specific oligosaccharide structures exposed on the surface of the glycoprotein.

关 键 词：Cytotoxic activity bladder cancer hemocyanin from Rapana venosa. 

分 类 号：Q969.436.5[生物学—昆虫学] TQ463.54[化学工程—制药化工]