Local and Systemic Immunity Research of Herpetic and ChlamydiaI-Herpetic Infection  

作　　者：Elena Vladimirovna Markelova Natalia Sergeevna Chepurnova Marina Sergeevna Tulupova Alexander Viktorovich Karaulov Elena Valeryevna Bayba-rina Kirill Vasilyevich Teterlev Valeria Vologina Elena Vladimirovna Markelova;Natalia Sergeevna Chepurnova;Marina Sergeevna Tulupova;Alexander Viktorovich Karaulov;Elena Valeryevna Bayba-rina;Kirill Vasilyevich Teterlev;Valeria Vologina(Department of Normal and Pathological Physiology, Pacific State Medical University, Ministry of Healthcare of the RussianFederation, Vladivostok 690002, Russian Federation;Department of Obstetrics and Gynaeeology with Course of Perinatology, Peoples'Friendship University of Russia, Ministry ofEducation and Science of the Russian Federation, Moscow 11719, Russian Federation;Department of Clinical Immunology and Allergology, LM. Sechenov First Moscow State Medical University, Ministry ofHealthcare and Social Development of the Russian Federation, Moscow 119991, Russian Federation)

机构地区：[1]Department of Normal and Pathological Physiology, Pacific State Medical University, Ministry of Healthcare of the RussianFederation, Vladivostok 690002, Russian Federation [2]Department of Obstetrics and Gynaeeology with Course of Perinatology, Peoples'Friendship University of Russia, Ministry ofEducation and Science of the Russian Federation, Moscow 11719, Russian Federation [3]Department of Clinical Immunology and Allergology, LM. Sechenov First Moscow State Medical University, Ministry ofHealthcare and Social Development of the Russian Federation, Moscow 119991, Russian Federation

出　　处：《Journal of US-China Medical Science》2016年第4期200-205,共6页美中医学（英文版）

摘　　要：Investigation of the immune status and TNF-α, IFN7 and IL-10 concentration in the ejaculate and venous blood serum of 100 men with STI （marked as main group （MG）） has been conducted. MG men were divided into 2 subgroups： 50 men with chronic viral urethritis （genital herpes--herpetic urethritis （HU）） and 50 patients with c viral-bacterial urethritis （genital herpes, associated with chlamydiosis-herpetic-chlamydial urethritis （HCU））. Comparative group （control group） were included 20 apparently healthy male-volunteers. More perceptible disfunctions of the local and systemic immunity have been revealed in patients with viral-bacterial urethritis： elevating of CD3＋ CD25＋ expression as well as indicators of late negative activation markers have been recorded on the background of phagocytosis indicators reducing, reliable rising of TNFα level in the venous blood serum have been marked, similar cytokine level in the ejaculate has been considerably higher as compared with the herpetic urethritis group and controls; also IFN-α/IL- 10 ratio lowering has been noted either in the venous blood serum, or in the seminal fluid compared with the control group.

关 键 词：Immune shams CYTOKINES EJACULATE HERPES chlamydiosis. 

分 类 号：S858.292[农业科学—临床兽医学] S858.312.4[农业科学—兽医学]