2-芳基丙酸酯的合成新法  

New Synthesis of Ethyl 2-Arylpropionate

作　　者：程青芳[1] 陈梅筠 汪洪湖 

机构地区：[1]安徽技术师范学院,安徽凤阳233100 [2]蚌埠丰原医药科技发展有限公司,安徽蚌埠233010

出　　处：《中国医药工业杂志》2002年第8期370-371,共2页Chinese Journal of Pharmaceuticals

摘　　要：先将α-溴代丙酸乙酯与金属锌反应制得有机锌制剂 ,然后在苯膦合镍 (0 )催化下直接与溴化芳烃交叉偶联 ,可制得 2 -芳基丙酸酯 ,反应条件温和产物易提纯 ,总收率 5 0 %以上。Ethyl 2 arylpropionate was synthesized from 2 bromopropionic acid ethyl ester and zinc to give the zinc reagent, and then by cross coupling reaction with Ar Br using Ni(PPh 3) 4 as catalyst in an overall yield of above 50%. The reaction conditions were mild, and the product was easily purified.

关 键 词：2-芳基丙酸酯 锌试剂 交叉偶联 合成 

分 类 号：O623.624.1[理学—有机化学]