西安地区妊娠期妇女TORCH检测及感染特点分析  

Analysis of TORCH Infection and Its Characteristic in Pregnant Women in Xi’an Area

作　　者：施瑞洁[1] 刘文康[1] 李玲[1] 白国艳 杨倩[1] 吴玲芝[1] 闫福堂[1] 

机构地区：[1]陕西省人民医院检验科

出　　处：《现代检验医学杂志》2016年第6期23-27,共5页Journal of Modern Laboratory Medicine

基　　金：国家自然科学基金资助项目(NO.81272856)

摘　　要：目的：探讨西安地区妊娠期妇女 TORCH 感染特点。方法利用酶联免疫吸附试验（enzyme-linked immunosor-bent assay，ELISA）检测2014～2015年10373例妊娠期妇女血清中抗弓形虫（toxoplasma gondii，TOX）抗体 IgM／IgG、抗风疹病毒（rubella virus，RV）IgM／IgG、抗巨细胞病毒（cytomegalovirus，CMV）抗体 IgM／IgG、抗单纯疱疹病毒 II型（herpes simplex virus II type，HSV-II）抗体IgM／IgG。结果在10373例受检者中TOX-IgM，RV-IgM，CMV-IgM和 HSV-II-IgM的阳性率分别为0.02％（2／10373），0.07％（7／10373），0.27％（28／10373）和0.01％（1／10373），TOX-IgG，RV-IgG， CMV-IgG和 HSV-II-IgG的阳性率分别为3.81％（395／10373），90.63％（9401／10373），93.70％（9719／10373）和4.92％（510／10373），未感染这四种病原体的占0.64％（66／10373）；2014年36～40岁受检者血清中 HSV-II-IgG阳性率最高（χ2＝57.16，P＝0.000），而TOX-IgG，RV-IgG和 CMV-IgG阳性率在各年龄段之间差异无统计学显著性意义（P＞0.05）；2015年16～20岁受检者血清中 TOX-IgG，RV-IgG 和41～45岁受检者血清中 HSV-II-IgG 阳性率最高（χ2＝18.03～31.94，P＝0.000），而CMV-IgG阳性率在受检者各年龄段之间差异无统计学显著性意义（P＞0.05）；2014年21～25岁受检者中TOX-IgG和21～40岁 RV-IgG 阳性率均明显高于2015年同年龄组受检者（χ2＝6.918～13.857，P＝0.000～0.025），2014年21～30岁受检者中CMV-IgG阳性率和 HSV-II-IgG阳性率均明显低于2015年（χ2＝4.235～13.267，P＝0.000～0.04）。结论西安地区妊娠期妇女TORCH感染尚处于低水平，RV和 CMV为主要感染病原体，各年度和不同年龄段妊娠期妇女感染有所差异，该研究为TORCH的流行病学以及防治提供实验资料和依据。Objective To explore the characteristic of TORCH infection in pregnant women in Xi’an area.Methods Toxo-plasma gondii （TOX）-IgM/IgG,rubella virus （RV）-IgM/IgG,cytomegalovirus （CMV）-IgM/IgG and herpes simplex virus II type （HSV-II）-IgM/IgG were detected in serum of 10 373 pregnant women during 2014~2015 with enzyme-linked immu-nosorbent assay （ELISA）.Results The positive rates of TOX-IgM,RV-IgM,CMV-IgM and HSV-II-IgM were 0.02% （2/10 373）,0.07%（7/10 373）,0.27% （28/10 373）and 0.01% （1/10 373）,respectively and those of TOX-IgG,RV-IgG, CMV-IgG and HSV-II-IgG were 3.81% （395/10 373）,90.63% （9 401/10 373）,93.70% （9 719/10 373）and 4.92%（510/10 373）,respectively.There was 0.64 percent （66/10 373）of examinees who were infected by none of TORCH patho-gen.The positive rate of HSV-II-IgG in examinees 36~40 years old was highest among all age groups （χ2=57.16,P=0.000）,but there was no significant difference for positive rates of TOX-IgG,RV-IgG and CMV-IgG in all age groups （P〉0.05）.The highest rates of TOX-IgG and RV-IgG in 16~20 age group,HSV-II-IgG in 41~45 age group were detected （χ2=18.03~31.94,P=0.000）,but there was no statistically difference for CMV-IgG in all age groups （P〉0.05）.The posi-tive rates of TOX-IgG in examinees in 21~25 age group and RV-IgG in those in 21~40 age group in 2014 were significantly higher than those in 2015 （χ2=6.918~13.857,P=0.000~0.025）,but those of CMV-IgG and HSV-II-IgG in 21~30 age group in 2014 were less than those in 2015 （χ2=4.235~13.267,P=0.000~0.04）.Conclusion RV and CMV were prima-ry pathogens in TORCH infection for pregnant women in Xi’an area and there were variances of TORCH infection charac-teristic in different years and age groups,which provided experimental data and basis for epidemiology and prevention of TORCH.

关 键 词：妊娠期妇女 TORCH 感染特点 

分 类 号：R37[医药卫生—病原生物学] R715[医药卫生—基础医学]