ApoE基因多态性与糖尿病肾病的相关性研究进展  

Correlation between ApoE gene polymorphism and diabetic nephropathy

作　　者：姜永玮[1] 马亮[1] 刘倩[1] 丛笑[1] 曹永彤[1] 

机构地区：[1]中日友好医院检验科,北京100029

出　　处：《中华检验医学杂志》2016年第12期974-977,共4页Chinese Journal of Laboratory Medicine

摘　　要：糖尿病肾病是糖尿病最严重的慢性并发症之一，是导致终末期肾病的主要原因。流行病学研究表明遗传易感性是糖尿病肾病发生发展的重要因素。载脂蛋白E（ApoE）基因的外显子4编码区域存在多态性，参与脂质代谢，被认为是糖尿病肾病遗传易感性的候选基因。通过对病例对照研究、前瞻性随访研究、荟萃分析的结果进行综述，ApoE E2等位基因可能是糖尿病肾病的遗传危险因素之一，而E4等位基因可能是糖尿病肾病的保护性因素。 APOE可能通过参与体内脂代谢、调节细胞外基质生长因子的活性以及调节肾脏保护基因表达等多方面参与糖尿病肾病的发生过程，具体的作用机制尚需要进一步研究证实。Diabetic nephropathy （ DN） is one of the most serious chronic complications of diabetes and it is the main reason leading to end-stage renal disease.Epidemiological studies have shown that genetic susceptibility is one of the important factors in the development of DN . Regions coded by exon 4 of apolipoprotein E （ ApoE ） gene involved in lipid metabolism , which is considered to be a candidate susceptible gene for diabetic nephropathy .Articles on the relationship of APOE and diabetic nephropathy including case-control study , prospective follow-up study and meta-analysis are reviewed , and the conclusion suggests that APOE E2 allele may be one of the genetic risk factors for DN , and APOE E4 allele may be a protective factor.APOE may play its role in the development of DN through the participation in the lipid metabolism, regulation of cell growth factor activity in extracellular matrix and regulating gene expression in kidney protection and other aspects .However, the detailed mechanism of APOE polymorphism in diabetic nephropathy is unclear and needs further research .

关 键 词：糖尿病肾病 载脂蛋白E类 多态现象 遗传 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学] R440[医药卫生—临床医学]