载脂蛋白M-1-磷酸鞘氨醇轴与动脉粥样硬化  

The relationship between the apolipoprotein M-sphingosine.l-phosphate axis and atherosclerosis

作　　者：谭丽[1] 胡敏[1] 

机构地区：[1]中南大学湘雅二医院检验科,长沙410011

出　　处：《中华检验医学杂志》2016年第12期983-987,共5页Chinese Journal of Laboratory Medicine

摘　　要：载脂蛋白M－1－磷酸鞘氨醇轴（ apoM－S1P axis）是一条由apoM、S1P和S1PR构成的信号通路。血浆apoM是载脂蛋白家族成员，主要结合高密度脂蛋白（ HDL ），而HDL与心血管风险呈负相关。 apoM由于其特殊的亲脂性结合口袋，使其有能力结合S1P。 S1P是磷脂代谢的生物活性介质，在HDL中的含量是所有脂蛋白中最高的。 S1 P既可作为胞内第二信使，又可作为细胞间信号分子，通过激活G蛋白偶联受体（S1PR）发挥广泛的生物学效应。 apoM对动脉粥样硬化（As）的保护作用已较明确。近期研究表明，血浆S1P水平对AS也具有重要影响，ApoM－S1P轴可能在AS发生和发展的过程中发挥了重要作用。Apolipoprotein M-sphingosine-1-phosphate axis （ apoM-S1P axis ） signaling pathway consists of apolipoproteinM （apoM）, sphingosine-1-phosphate （S1P） and sphingosine-1-phosphate receptor （S1PR）.Plasma apoM belongs to lipocalinsuperfamily members , and is mainly associated to high density lipoprotein（ HDL）, whereas HDL-cholesterol correlates inversely with cardiovascular risk .The ability of apoM to bind S1P is due to a lipophilic binding pocket within the lipocalin structure of the apoM molecule . S1P, a bioactive mediator of phospholipid metabolism , predominantly abound in HDL among all lipoproteins.S1P can not only be used as intracellular second messengers , but also as intercellular signal molecules, activating of G protein-coupled receptors （S1PR） to mediate various physiological functions.It′s clear that apoM protects human beings from atherosclerosis .Furthermore, recent studies showed that S1P has a significant impact on atherosclerosis , and ApoM-S1P axis may play a important role in the pathogenesis or progression of atherosclerosis .

关 键 词：动脉粥样硬化 载脂蛋白类 脂笼蛋白质类 溶血磷脂素类 鞘氨醇 

分 类 号：R543.5[医药卫生—心血管疾病] R446.1[医药卫生—内科学]