磁共振波谱和mDIXON-Quant评价椎体骨髓脂肪含量的比较  

Comparison between magnetic resonance spectroscopy and mdixon-Quant in measuring bone marrow fat

作　　者：孙金磊[1] 李葆青[1] 王月卿[1] 王雷[1] 刘丹[1] 程晓光[2] 张勇[2] 端木羊羊 

机构地区：[1]首都医科大学石景山教学医院北京市石景山医院医学影像科,北京100043 [2]北京积水潭医院放射科,北京100035

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2016年第4期396-401,共6页Chinese Journal Of Osteoporosis And Bone Mineral Research

摘　　要：目的采用磁共振波谱(magnetic resonance spectroscopy,MRS)和m DIXON-Quant两种方法测量同一组患者L3椎体骨髓脂肪分数(fat fraction,FF),比较两种方法测量结果的相关性。方法对50例行腰椎MRI检查的患者均进行MRS和m DIXON-Quant扫描,获取L3椎体FF。结果 MRS和m DIXON-Quant测量L3椎体FF类内相关系数(intraclass correlation coefficient,ICC)是0.888(P=0.000),通过Bland-Altman分析发现50例配对数据95%一致性界限(-14.201,14.508),2%(1/50)的点在95%一致性界限以外。结论 MRS和m DIXON-Quant对椎体骨髓脂肪含量的测量高度相关,m DIXON-Quant可用于评价椎体骨髓脂肪含量,未来可能得到更广泛的应用。Objective To compare the measurements of bone marrow fat between magnetic resonance spec- troscopy （MRS） and mDIXON-Quant. Methods MRS and mDIXON-Quant scans were performed in 50 patients （ 19 males and 31 females） aged 30 to 86 years （ mean age 58.4 years） with routine lumbar MRI examination to quantify the bone marrow FF of the L3 vertebra which had no obvious deformation. Signal intensity in mDIXON- Quant was analyzed from the same location and size of the single-voxel 1H MRS measurement. Results Correlation between the two MR methods measured bone marrow FF was 0. 888 by ICC （ P = 0. 000） in the L3 vertebra. The paired difference data in 50 cases was d = O. 153, the standard deviation of difference was 7. 167, and the 95% consistent boundaries was （ - 14. 201, 14. 508） by Bland-Altman analysis. There was only 2% （1/50） points outside the 95% consistency boundaries by Bland-Ahman analysis. Conclusion There are good correlations be- tween MRS and mDIXON-Quant for bone marrow fat quantification. MDIXON-Quant is a potentially useful tool in evaluating the bone marrow changes, which may be more widely used.

关 键 词：磁共振波谱 MDIXON-Quant 椎体 骨髓脂肪 

分 类 号：R445.2[医药卫生—影像医学与核医学]