联合检测β_2-微球蛋白和胱抑素C对子痫前期早期肾损伤辅助诊断的临床意义  

To explore the clinical significance of the early kidney damage of the preeclampsia auxiliary diagnosis by the β_2-Microglobulin and the Cystatin C joint detection

作　　者：陈明[1] 

机构地区：[1]射洪县中医院检验科,四川射洪629000

出　　处：《中国实验诊断学》2016年第9期1468-1470,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨联合检测β_2-微球蛋白和胱抑素C对子痫前期早期肾损伤辅助诊断的临床意义。方法选择120例2013年1月-2015年12月间确诊为子痫前期的孕妇患者组成实验组,根据肾小球滤过率结果分为实验A组(肾功能正常组,肾小球滤过率≥90ml/min/1.73m2)和实验B组(肾功能异常组,肾小球滤过率<90ml/min/1.73m2),选择同期进行健康体检正常孕妇60例组成对照组,检测所有孕妇的血清β_2-微球蛋白、胱抑素C、肌酐、尿素浓度水平,对结果进行综合分析。结果 120例子痫前期孕妇中53例存在肾功能异常(44.17%)。实验B组β_2-微球蛋白、胱抑素C、肌酐、尿素浓度水平和肾小球滤过率均明显高于对照组和实验A组,差异具有统计学意义(P<0.05),但实验A组和对照组间无明显统计学差异(P>0.05)。对于子痫前期早期肾损伤患者联合检测β_2-微球蛋白和胱抑素C的敏感性明显高于单项检测结果(P<0.05),但特异性有所降低;Youden指数显示联合检测β_2-微球蛋白和胱抑素C结果>胱抑素C>β_2-微球蛋白。结论β_2-微球蛋白和胱抑素C两项指标均是辅助诊断子痫前期早期肾损伤疾病的有效指标,联合检测能够提高敏感性,降低漏诊风险,值得临床推广。Objective To explore the clinical significance of the early kidney damage of the preeclampsia auxiliary diagnosis by theβ_2-Microglobulin and the Cystatin C joint detection.Methods Choosing 120 cases of patients with the preeclampsia disease for the experimental group,according to the results of the Glomerular filtration rate we can divide the experimental group into the experimental group A（the normal renal function group,Glomerular filtration rate≥90ml/min/1.73m2）and the the experimental group B（the abnormal renal function group,Glomerular filtration rate90ml/min/1.73m2）,choosing 60 cases of healthy check-up for the control group,testing theβ_2-Microglobulin and the Cystatin C,analyze the results comprehensively.Results 53 cases of preeclampsia pregnant women in 120 cases were abnormal renal function（44.17%）.There were significantly higher of the experimental group B of theβ_2-Microglobulin,the Cystatin C,Creatinine,Urea results and the Glomerular filtration rate than the experimental group A and the control group（P〈0.05）,but there were no significantly difference between the the experimental group A and the control group（P〉0.05）.There were significantly higher of the susceptibility by theβ2-Microglobulin and the Cystatin C joint detection than the results of single detection for the early kidney damage of the preeclampsia patients（P〈0.05）.The Youden was the results of theβ_2-Microglobulin and the Cystatin C joint detection〉Cystatin C〉β2-Microglobulin.Conclusion There are both effective indexes of theβ_2-Microglobulin and the Cystatin C for the early kidney damage of the preeclampsia auxiliary diagnosis,joint detection can improve the sensitivity and reduce the risk of missed diagnosis,it is worth to be popularized in clinic.

关 键 词：子痫前期 Β2-微球蛋白 胱抑素C 

分 类 号：R714.244[医药卫生—妇产科学] R446.1[医药卫生—临床医学]