β-catenin蛋白在颈椎间盘突出症中的表达及临床意义  

The expression and clinical significance of β-catenin protein in the cervical intervertebral disc herniation

作　　者：特木尔巴 刘大龙[2] 姚云壮 黄建[2] 王壮壮[2] 张炳近 臧虎[2] Temuerba LIU Da-long YAO Yun-zhuang et al(Department of Orthopaedics, The affiliated hospital of Inner Mongolia University of Nationalities, Tongliao 028000 ,Chin)

机构地区：[1]内蒙古民族大学附属医院骨科,内蒙古通辽028000 [2]吉林大学中日联谊医院脊柱外科

出　　处：《中国实验诊断学》2016年第10期1677-1679,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的研究颈椎间盘突出症患者及正常颈椎间盘中β-catenin蛋白的表达,从而分析其临床意义。方法采用免疫组化SP方法分别检测16例颈椎间盘突出症患者,5例同期因颈段脊柱创伤手术治疗患者的间盘组织中β-catenin蛋白的表达,从而分析其临床意义。结果β-catenin蛋白在退变颈椎间盘组织中有高表达,而对照组正常颈椎间盘组织中无表达,两组间有统计学差异(P<0.01)。结论颈椎间盘退变过程中β-catenin蛋白起一定作用。Objective To study the expression of β-catenin protein in cervical intervertebral disc herniation,and to analyze the clinical significance.Methods The expression of β-catenin protein in 16 cases of cervical intervertebral disc herniation and 5cases normal cervical intervertebral disc tissue were detected by immunohistochemistry.Results β-catenin protein showed high expression in the degeneration of cervical intervertebral disc tissue.However,it has no expression in the control group of normal cervical intervertebral disc tissue,it has statistical significance（P〈0.01）.Conclusion β-catenin protein might play a role in the development of degeneration of cervical intervertebral disc tissue

关 键 词：颈椎间盘突出症 免疫组化 Β-CATENIN蛋白 

分 类 号：R681.53[医药卫生—骨科学]