甲状腺功能亢进症患者的肺动脉压力水平及其与血浆B型钠尿肽的相关性研究  

Correlations Between Pulmonary Artery Pressure and Bnp Levels in Plasma of Hyperthyroid Patients

作　　者：汪冬梅[1] 刘丹[1] 郝凤杰[1] 王立东[1] 刘海英[1] 

机构地区：[1]承德市中心医院内分泌科,河北承德067000

出　　处：《解放军预防医学杂志》2016年第6期869-871,共3页Journal of Preventive Medicine of Chinese People's Liberation Army

基　　金：河北省卫生厅科研基金项目;河北省医学科学重点研究课题(No.20160301)

摘　　要：目的通过检测不同阶段甲亢病人的肺动脉压、血浆B型钠尿肽(BNP)水平,初步探讨甲亢患者肺动脉压变化特点及其与血浆BNP的相关性。方法采用微粒酶免疫测定法测定90例研究对象的血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)和促甲状腺素(TSH)强度。根据其甲状腺功能分成三组,分别测量肺动脉压和血浆BNP水平。结果临床甲亢组、亚临床甲亢组平均肺动脉压力和肺高压患病率均高于健康对照组;临床甲亢组平均肺动脉压力高于亚临床甲亢组(P<0.05),肺高压患病率亦高于亚临床甲亢组,但差别无统计学意义(P>0.05)。临床甲亢组和亚临床甲亢组的血浆BNP值均远远高于健康对照组(P<0.05);但临床甲亢组和亚临床甲亢组的血浆BNP值组间比较,差异不明显(P>0.05)。肺动脉压水平与TSH呈负相关;而与FT3、FT4、血浆BNP呈正相关(P<0.05)。结论肺动脉压力水平随甲亢病情的加重而增高,且与血浆BNP值呈正相关性,可用于评估甲亢患者肺动脉高压发生的风险性。Objective To explore the correlations between pulmonary artery pressure changes and plasma BNP levels by detecting related indexes of patients with hyperthyroidism in different stages. Methods Ninety cases were divided into three groups in accordance with their thyroid function. The levels of free triiodothyronine （Fq3）, free thyroxine （FT4） and thyroid stimulating hormone （TSH） in serum were detected using microparticle enzyme immunoassay method and their pulmonary artery pressure and plasma BNP levels were measured. Results The mean pulmonary artery pressure and incidence of pulmonary hyper- tension were higher in clinical hyperthyroidism and subclinical hyperthyroidism groups than that in control group. The mean pul- monary artery pressure in clinical hyperthyroidism group was higher than that of the subclinical hyperthyroidism group （P〈0.05）, so was the incidence of pulmonary hypertension, but the difference was not statistically significant （P〉0.05）. Plasma BNP val- ues in clinical hyperthyroidism and subclinical hyperthyroidism groups were much higher than those in healthy control group （P〈 0.05 ）, but there was no significant difference between the clinical hyperthyroidism and subclinical hyperthyroidism groups （P〉 0.05 ）. Pulmonary artery pressure was negatively correlated with TSH levels, but was positively correlated with levels of FF3, FT4 and plasma BNP （P〈0.05）. Conclusion The level of pulmonary artery pressure increases with the severity of hyperthyroid- ism and is positively correlated with plasma BNP values so that it can be used to assess the risk of pulmonary hypertension in pa- tients with hyperthyroidism.

关 键 词：甲状腺功能亢进症 肺动脉高压 B型钠尿肽 

分 类 号：R582.1[医药卫生—内分泌]