滋阴清热法治疗阴虚内热型系统性红斑狼疮临床疗效观察  

Curative Observation of Applying Ziyin Qingre Therapy in the Treatment of Yin-deficiency Interior-heat Type SLE

作　　者：赵浩[1] 王丹[2] 薛鸾[2] 李奔[2] 杨月[2] 

机构地区：[1]上海中医药大学附属上海市中西医结合医院急诊科,上海200082 [2]上海中医药大学附属岳阳中西医结合医院风湿科,上海200437

出　　处：《四川中医》2016年第12期96-99,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的：研究滋阴清热法治疗阴虚内热型系统性红斑狼疮（SLE）的临床疗效。方法：随机选取2014年7月~2016年1月间本院收治系统性红斑狼疮患者100例,其中男女分别为22例和78例,随机成为2组即A组为研究组50例,B组为对照组50例。B组采用醋酸泼尼松＋予环磷酰胺治疗方案,A组在B组方案的基础上联合滋阴清热治疗方案,通过A、B两组的治疗效果对比进行分析。结果：A、B两组患者体重的对比,差异无统计学意义（P〉0.05）。A、B两组疾病疗效对比,并通过Ridit进行检验显示A组的总有效率为92.00%比B组的84.00%高,且差异有统计学意义（P〈0.05）。A、B两组中医证候疗效对比,并通过Ridit进行检验显示A组的总有效率为94.00%比B组的52.00%高,且差异有统计学意义（P〈0.05）。A组患者治疗前后的SLE-DAI评分别为（9.63±2.84）和（3.74±0.57）,且治疗前后对比差异有统计学意义（P=0.001）;B组患者治疗前后的SLE-DAI评分别为（9.38±2.53）和（4.62±1.31）,且治疗前后对比有明显差异（P=0.003）。A组和B组间治疗前的对比,有明显差异（P=0.712）;A组和B组间治疗后的对比有明显差异（P=0.031）。A组患者治疗前后中医临床证候积分评分别为（9.6313.86±5.27）和（3.67±1.54）,且治疗前后对比差异有统计学意义（P=0.002）;B组患者治疗前后的中医临床证候积分评分别为（14.02±5.68）和（6.48±2.86）,且治疗前后对比有明显差异（P=0.004）。A组和B组间治疗前的对比,有明显差异（P=0.827）;A组和B组间治疗后的对比,有明显差异（P=0.027）。A、B两组内的治疗前后实验室指标对比,通过χ^2检验后有明显差异（P〈0.05）。A、B两组间的治疗后对比有明显差异（P〈0.05）。A、B两组间治疗前的激素使用情况对比,差异无统计学意义（P=0.082）;A、B两组间治疗后的激素使用情况对比,差异有统计学意义（P=0.002）;A、B两组间�Objective： To study the clinical efficacy of using Ziyin Qingre Therapy in the Treatment of Yin-deficiency type systemic lupus erythematosus（ SLE）. Methods： Randomly selected 100 cases in our hospital patients with systemic lupus erythematosus between July 2014 and January 2016,in which men and women were 22 cases and 78 cases were randomly became two groups,namely the study group（ A group） and controlled group（ B group）,each group had 50 patients. The group B was given cyclophosphamide＋prednisone regimen,the group A was given Ziyin Qingre Therapy on the basis of group B,comparative analysis was done through group A and B treatment. Results： There had no statistically significant difference between the two groups on weight（ P〈0. 05）. The total effective rate of the group A was 92. 00%,it was better than the group B which was 84. 00%,and the difference was statistically significant（ P〉0. 05）. TCM syndrome comparison between the two groups showed the total ef-fective rate of group A（ 94. 00%） was higher than that of the group B（ 52. 00%）,and the difference was statistically significant（ P〈0. 05）. The A group of patients with SLE-DAI assessment before and after treatment were（ 9. 63± 2. 84） and（ 3. 74±0. 57）,and the comparison of before and after treatment difference was statistically significant（ P = 0. 001）; SLE-DAI commentary before and after the treatment was in group B was（ 9. 38 ± 2. 53） and（ 4. 62 ± 1. 31）,and the comparison before and after treatment was significantly different（ P = 0. 003）. Contrasting between the group A and the group B before treatment,there was no significant differences（ P = 0. 712）; between group A and group B comparison after treatment were significantly different（ P =0. 031）. The A group of patients before and after treatment respectively SLEFI comments were（ 9. 6313. 86±5. 27） and（ 3. 67±1. 54）,and the comparison of before and after treatment difference was statistically significant（ P = 0.

关 键 词：滋阴清热法 阴虚内热型 系统性红斑狼疮 

分 类 号：R593.24[医药卫生—内科学]