坤泰胶囊联合雌激素补充疗法治疗绝经综合征的疗效分析  

Kuntai Capsules Combined with Estrogen Replacement Therapy in the Treatment of Menopausal Syndrome

作　　者：季滢[1] 孙海洪[1] 胡小玲[1] JI Ying SUN Hai -hong HU Xiao- ling(Obstetrics and Gynecology Department, Rugao Municipal People＇s Hospital,Rugao 226500, Chin)

机构地区：[1]江苏省如皋市人民医院妇产科,江苏如皋226500

出　　处：《中医药学报》2016年第6期66-70,共5页Acta Chinese Medicine and Pharmacology

摘　　要：目的:探讨坤泰胶囊联合雌激素补充疗法对绝经综合征患者血清性激素水平及绝经指数(KMI)的影响。方法:选取该院妇产科2015年1月—9月收治的84例绝经综合征患者,将其按照随机数字法随机均分为对照组和观察组,对照组采用常规的雌激素补充疗法,给予药物戊酸雌二醇(补佳乐)2 mg,1次/天;观察组采用坤泰胶囊联合雌激素补充疗法,给予补佳乐1 mg,1次/天,同时口服坤泰胶囊4粒/次,3次/天;两组均连续治疗12周。在治疗前与治疗第4、8、12周后分别计算、比较各组的绝经指数(KMI),测量和评估两组患者治疗前和治疗12周后血清相关性激素水平、子宫内膜厚度及不良反应的发生情况。结果:治疗12周后对照组和观察组总有效率分别为64.2%和83.3%,观察组较对照组疗效更为显著(P<0.05);治疗后第4,8,12周,两组KMI评分均明显下降(P<0.05),且观察组在各时间节点测得KMI评分下降均更为明显(P<0.05);药物干预12周后两组血清雌二醇(E2)水平及子宫内膜厚度较治疗前有明显升高(P<0.05),卵泡刺激素(FSH)水平较治疗前明显下降(P<0.05),且观察组较对照组血清E2、FSH和子宫内膜厚度变化幅度更为明显(P<0.05)。结论:坤泰胶囊联合雌激素补充疗法能有效改善绝经综合征相关症状和血清相关激素水平,该疗法疗效显著,值得进一步研究和推广。Objective： To investigate the Kuntai capsules combined with estrogen replacement therapy for menopausal syndrome patients according to serum sex hormone levels and the impact index （KMI） menopause. Methods： Choose 84 menopause syndrome patients from obstetrics and gynecology department in the hospital from January 2015 to September 2015. According to the method of random numbers they were divided into a control group and an observation group. The control group was treated with normal estrogen replacement therapy, giving pentanoic acid estradiol （Bujiale） 2 mg, 1 time/day; the observation group was treated with Kuntai capsules combined with estrogen replacement therapy, giving Bujiale 1 mg, 1 time/day, orally Kuntai capsules 4 granules/time, 3 times per day; both groups were for the treatment of 12 weeks. Before treatment and 4, 8, 12 weeks after treatment, respectively, calculation, comparison between two groups according to menopause index （KMI）. Measurement and evaluation of two groups of patients before and after 12 weeks treatment were according to serum sex hormone levels and the occurrence of adverse reactions of endometrial thickness. Results： 12 weeks after treatment in the control group and observation group the total effective rates were 64.2% and 83.3%, respectively. In the observation group in the curative effect was more significant （ P 〈 0. 05 ） ; 4 weeks after treatment,in two groups the KMI scores were significantly lower （ P 〈 0.05 ）, and in the observation group the KMI scores were decreased more significantly （ P 〈 0.05 ） ; 12 weeks after intervention, in two groups the serum estradiol （E2） levels and endometrial thickness were significantly increased compared with those before treatment （ P 〈 0. 05 ） follicle -stimulating hormone （FSH） levels were decreased obviously compared with those before treatment（ P 〈 0.05 ）, and in the observation group the serum E2, FSH and endometrial thickness variation were more obvious （P 〈 0.05 ）. Conc

关 键 词：坤泰胶囊 雌激素补充疗法 联合疗法 绝经综合征 

分 类 号：R271.116[医药卫生—中医妇科学]