益气解毒通络法与恩替卡韦联合应用治疗乙肝肝硬化(代偿期)的随机对照研究  

Effect of Replenishing Qi,Detoxication and Dredging Collateral Method Combined with Entecavir in Treatment of Hepatitis B Cirrhosis (Compensated)

作　　者：蔡小旗 张达坤[1] 张清[1] 

机构地区：[1]海南省中医院消化肝胆内科,海南海口570203

出　　处：《辽宁中医杂志》2016年第12期2566-2569,共4页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的:探讨益气解毒通络法与恩替卡韦联合应用治疗乙肝肝硬化(代偿期)的临床疗效。方法:选取海南省中医院门诊及住院乙肝后肝硬化代偿期患者100例,按随机数字表法分组,对照组50例予以恩替卡韦治疗,研究组50例予以恩替卡韦联合益气解毒通络法治疗,观察并记录两组患者肝功能、肝纤维化及影像学指标,同时对比临床疗效及不良反应状况。结果:对照组治疗有效率76.00%低于研究组治疗有效率92.00%,具有统计学意义(P<0.05);与对照组比较,研究组治疗后血清ALT、AST、TBi L低于对照组,血清ALB高于对照组,治疗后血清LN、HA、PCⅢ和CⅣ低于对照组,治疗后门静脉内径、脾静脉内径、脾脏厚度低于对照组,门脉最大流速高于对照组,具有统计学意义(P<0.05)。结论:益气解毒通络法与恩替卡韦联合应用对乙肝后肝硬化(代偿期)临床疗效显著,明显改善肝功能指标,延缓病情进展。Objective ： To investigate the effect of replenishing Qi, detoxication and dredging collateral method combined with Entecavir in the treatment of Hepatitis B cirrhosis （compensated）. Methods：A hundred cases with hepatitis B cirrhosis （compen- sated） in outpatient department of our hospital were selected and according to random number table grouping were divided into 2 groups. Control group （50 cases） received Entecavir and the experiment group （50 cases） added the method of replenishing Qi, detoxication and dredging collateral. Liver function,liver fibrosis and imaging parameters and the clinical efficacy and adverse reaction were compared. Results ：The effective rate in control group （76.00%） was lower than the experiment group＇s （92.00%） with significant difference （P 〈 0. 05 ）. And compared with the control group, the serum ALT, AST and TBIL in the experiment group were lower than those of the control group after the treatment. The serum albumin （ALB） was higher and the serum LN, HA, PCⅢ and CⅣ were lower than those of the control group. The backdoor vein diameter, spleen vein and thickness of spleen treatment were lower than those of the control group. The maximum velocity of the portal vein was higher than that of the control group with statistical significance （ P 〈 0. 05）. Conclusion ： Replenishing Qi, detoxication and dredging collateral combined with Entecavir in the treatment of hepatitis B cirrhosis （compensated） was effective and can obviously improve liver function index and delay the progress of the disease.

关 键 词：益气解毒通络法 恩替卡韦 乙肝后肝硬化 

分 类 号：R657.31[医药卫生—外科学]