桥本甲状腺炎患者甲状腺肿大程度与自身抗体及组织学改变的关系  

The relationship between the thyroid enlargement degree and thyroid autoantibodys,histologic changes for patients with hashimoto thyroiditis

作　　者：肖剑鹏[1] 林忆阳[1] 徐向进[1] 

机构地区：[1]南京军区福州总医院内分泌科,福建福州350025

出　　处：《川北医学院学报》2016年第6期855-856,921,共3页Journal of North Sichuan Medical College

基　　金：福州总医院院内计划项目(2013239)

摘　　要：目的:分析桥本甲状腺炎患者甲状腺肿大程度与自身抗体及组织学改变的关系,以期为临床诊疗提供参考。方法:选择2015年6月至2016年6月在本院接受诊疗的96例桥本甲状腺炎患者作为研究对象,依据甲状腺肿大程度将患者分为甲组(轻中度肿大,n=57)和乙组(重度肿大,n=39)。结果:甲组甲状腺淋巴细胞轻度浸润比例高于乙组(P<0.05),但重度浸润比例低于乙组(P<0.05)。甲组患者TPOAb、TGAb水平显著低于乙组患者(P<0.05)。Spearman等级相关分析显示,甲状腺淋巴细胞浸润程度与外周血TPOAb、TGAb均呈现显著正相关关系(P<0.05)。结论:桥本甲状腺炎患者的甲状腺肿大程度可能与疾病活动程度更为相关。Objective：To analyze the relationship between the thyroid enlargement degree and thyroid autoantibodys,histologic changes for patients with hashimoto thyroiditis. Methods：96 patients with hashimoto thyroiditis received treatment in our hospital from 2015 to 2016 were analyzed. Patients were divided into Group A （ mild-to-moderate enlargement, n = 57 ） and Group B （ severe enlargement,n = 39）by the thyroid enlargement degree. Results：Group A had a higher rate of light lymphocytic infiltrates （P 〈 0.05 ） , hut rate of severe lymphocytic infiltrates in Group A was lower than these of Group B （ P 〈 0.05 ）. Levels of TPOAb and TGAb in Group A was significantly lower than these in Group B patients, the difference was statistically significant （ P 〈 0. 05）. Correlation analysis showed that the lymphocytic infiltration degree had a significant positive correlation with TPOAb and TGAb （P 〈 0.05 ）. Conclusion： For hashimoto thyroiditis patients,the thyroid enlargement degree may be positive with disease activity.

关 键 词：桥本甲状腺炎 甲状腺自身抗体 淋巴细胞浸润 免疫 相关性 

分 类 号：R551.24[医药卫生—血液循环系统疾病]