新型黄连素席夫碱的合成与表征  

Synthesis and Characterization of Schiff Bases of Berberine

作　　者：朱万仁[1] 崔锋燕 李家贵[1] 黄肇宇[2] 

机构地区：[1]玉林师范学院化学与食品学院,广西玉林537000 [2]玉林师范学院生物与制药学院,广西玉林537000

出　　处：《玉林师范学院学报》2016年第5期42-48,共7页Journal of Yulin Normal University

基　　金：玉林市科技开发项目经费支助(玉市科能11042039)

摘　　要：席夫碱化合物具有多功能性,与中心原子形成配位形成金属配合物,使得它成为近代科学研究的热点.本文主要介绍以黄连素为原料,经Vilsmeier-Haak试剂(DMF/POCl_3)甲酰化,最后分别与水合肼、盐酸羟胺反应,生成黄连素席夫碱.本文探讨了黄连素甲酰化的最佳反应条件,中间体和产物分别用UV、IR进行了表征.Schiffbase compounds are mufti-functional, which has become a hot subject in contemporary research. This paper mainly introduces the process of synthesizing the Schiff base： with the berberine as raw material, after Vilsmeier-Haak reagent （DMF/POCl3） formylation, the formyl-berberine of intermediate was obtained. New Schiffs bases were synthesized by reaction with the intermediate and hydrazine hydrate, hydroxylamine hydrochloride respectively. The intermediate and Chiff bases were characterized by UV, IR.

关 键 词：黄连素 甲酰化 席夫碱 合成 

分 类 号：O621[理学—有机化学]