糖尿病神经病变血清维生素D与离子钙变化  

Analysis on the changes of serum levels of vitamin D and ionized calcium in diabetic neuropathy

作　　者：陈荃[1,2] 时照明[1] 

机构地区：[1]蚌埠医学院第一附属医院内分泌科,安徽蚌埠233000 [2]滁州市第一人民医院内分泌科,安徽滁州239000

出　　处：《热带医学杂志》2016年第12期1501-1503,共3页Journal of Tropical Medicine

摘　　要：目的探讨糖尿病周围神经病变患者治疗前后血清维生素D与血清离子钙变化的意义。方法选取2015年5-11月滁州市第一人民医院收治的153例糖尿病患者,将发生周围神经病变患者68例作为病变组,未发生周围神经病变患者85例作为未病变组;另选取同期本院健康体检者75例作为健康对照组。观察病变组和未病变组患者治疗前后血清维生素D、血清离子钙水平变化,并与健康对照组对比,以探讨糖尿病周围神经病变血清维生素D与血清离子钙的相关性。结果治疗前未病变组与健康对照组血清维生素D、血清离子钙比较差异无统计学意义(P>0.05),病变组相对于其他两组显著较低(P<0.05);治疗后,病变组相比于治疗前,血清维生素D明显升高(P<0.05),且三组组内比较差异无统计学意义(P>0.05),糖尿病周围神经病变患者血清维生素D与离子钙水平存在明显正向相关性(r=0.532,P<0.05)。结论糖尿病周围神经病变治疗前后血清维生素D与血清离子钙变化差异显著,且血清维生素D与血清离子钙之间呈正相关关系。Objective To discuss the significance of changes of serum vitamin D and serum ionized calcium levels in patients with diabetic peripheral neuropathy before and after treatment. Methods 153 cases of patients with diabetes mellitus treated in our hospital from May 2015 to November were selected as the research subjects, among which the patients who had peripheral neuropathy were selected as the lesion group, and the others who did not had peripheral neuropathy were as the non-lesion group. Another 75 cases of healthy volunteers in the physical examination center were as the healthy control group. The changes of serum vitamin D and serum ionized calcium levels of patients in the lesion group and non-lesion group before and after treatment were observed, which were compared with those of the healthy control group. Results Before treatment, there was no significant difference in serum vitamin D and serum calcium levels between the non-lesion group and the healthy control group（P〉0.05 ）, of which the lesion group was significantly lower than those in the other two groups （P〈0.05）. After treatment, compared with that before treatment, the serum vitamin D level in the lesion group was significantly increased （P〈0.05）, and there was no significant difference among the three groups （P〉0.05）. The serum vitamin D level had an obvious positive correlation with calcium ion level in patients with diabetic peripheral neuropathy （r=0.532, P〈0.05）. Conclusion The serum vitamin D and serum calcium levels in diabetic peripheral neuropathy before and after treatment were significantly different from those who had no peripheral neuropathy and normal people; serum vitamin D and serum calcium levels in diabetic peripheral neuropathy had a positive correlation.

关 键 词：糖尿病 周围神经病变 血清维生素D 血清离子钙 

分 类 号：R587.1[医药卫生—内分泌]