联合用药治疗妊娠合并支原体衣原体感染的疗效  

Efficacy of combination therapy for pregnant women with chlamydia and mycoplasma infection

作　　者：张余芳[1] 林尧[2] 蔡志善[1] 

机构地区：[1]海口市妇幼保健院药剂科,海南海口570203 [2]海口市妇幼保健院保健部,海南海口570203

出　　处：《热带医学杂志》2016年第12期1542-1544,共3页Journal of Tropical Medicine

摘　　要：目的探讨阿奇霉素联合头孢呋辛治疗妊娠合并支原体衣原体感染的临床效果,为临床药物治疗提供依据。方法选取2015年1月至2016年1月于海口市妇幼保健院接受治疗的妊娠合并支原体衣原体感染孕妇400例。患者按入院先后顺序随机分为观察组(n=200)与对照组(n=200),对照组给予阿奇霉素治疗,观察组在对照组基础上联用头孢呋辛治疗。结果观察组治疗有效率为100.00%,明显高于对照组的68.50%,差异有统计学意义(P<0.05)。治疗后,观察组不良反应发生率为12.50%,对照组不良反应发生率为11.50%,两组不良反应差异无统计学意义(P>0.05)。观察组胎膜早破、产褥感染、低体重儿发生率明显低于对照组(P<0.05)。结论阿奇霉素联合头孢呋辛治疗妊娠合并支原体衣原体感染的临床效果显著,有利于改善妊娠结局,且不良反应发生率低。Objective To analyze and discuss the efficiency of azithromycin cefuroxime treatment of pregnant women with chlamydia and mycoplasma infection to improve pregnancy outcomes, and provide the basis for clinical drug treatment. Methods 400 cases of pregnant women with chlamydia and mycoplasma infection were randomly divided into observation group and control group ; both groups of patients were given azithromycin for treatment ; the observation group was an addition of cefuroxime treatment. Results The response rate of the observation group was 100.00%, which was significantly higher than 68.50% of the control group （P〈0.05）. After treatment, the incidence of adverse reactions of the observation group had no significant different from that of the control group （ 12.50% and 11.50%, respectively） （P〉0.05）. In the observation group, incidence of premature rupture of membranes, puerperal infection, and low birth weight children was significantly lower than those of the control group （P〈0.05）. Conclusion Azithromycin combined with cefuroxime treatment for pregnant women with chlamydia and mycoplasma infection was effective, could help to improve pregnancy outcomes, and reduce the incidence of adverse reactions.

关 键 词：阿奇霉素 头孢呋辛 妊娠 支原体 衣原体 

分 类 号：R714.259[医药卫生—妇产科学]