我国三阴型乳腺癌临床病理特征与预后的Meta分析  

Clinicopathologic characteristics and prognosis of triple negative breast cancer in China:a Meta analysis

作　　者：陆国芬[1] 张辉挺[1] 马德奎[1] 区基文 张清[1] 

机构地区：[1]广东省肇庆市第一人民医院乳腺外科,广东肇庆526000

出　　处：《中国医药导报》2016年第35期96-101,共6页China Medical Herald

摘　　要：目的系统评价我国三阴型乳腺癌的临床病理特征及预后，为筛查高危人群，指导临床防治，评估预后提供循证基础。方法检索PubMed、EMBASE、CochraneLibrary、万方全文数据库、中国知网（CNKI）、中国生物医学文摘数据库（CBM）及维普数据库，系统收集我国三阴型乳腺癌临床病理特征及预后的相关文献，对纳入文献进行质量评估．采用RevMan5．2软件，建立随机或固定效应模型进行Meta分析。结果纳入20个临床对照试验，文献质量多为6～7颗星。三阴组与非三阴组乳腺癌之间差异有统计学意义（P〈0．05）的临床特征为发病年龄、乳腺癌家族史、组织学分级、腋窝淋巴结转移情况、病理分期、5年无瘤生存率、5年总生存率，OR值分别为2．48（95％CI=1．47～4．19）、2．05（95％CI=1．48～2．85）、2．19（95％CI=1．81～2．64）、1．64（95％CI=1．16～2．32）、1．59（95％CI=1．19～2．13）、0．49（95％CI=0．42．0．57）、0．46（95％CI=0．39～0．53）。两组间差异无统计学意义（P〉0．05）的临床特征为绝经情况、瘤体直径、病理类型，OR值分别为1．11（95％CI=0．99～1．25）、1．23（95％CI=0．90～1．68）、0．87（95％CI=0．74～1．01）。结论与非三阴型乳腺癌相比，三阴型乳腺癌患者发病年龄相对年轻，组织学分级及病理分期较高，淋巴结转移率高，与乳腺癌家族史相关，5年无瘤生存率及总生存率较差。Objective To systematically assess clinicopathological characteristics and prognosis of Chinese population with triple negative breast cancer, and to provide evidence-based medical proof for screening high risk groups,instruct the clinical prevention and treatment, estimate prognosis. Methods The databases including the PubMed, EMBASE, Cochrane Library, WanFang Data, CNKI, VIP and CBM were searched. Published studies concering clinieopathologie characteristics and prognosis of triple negative breast cancer in china were searched systemically and assessed. RevMan 5.2 software was used to establish random or fixed effects model for Meta analysis. Results Totally 20 studies were se- lected for Meta analysis, and most of them were classified as 6-7 stars. The age, family history of breast cancer, histo- logic grade, axillary lymph node metastasis, pathollogicstage, 5 years of tumor free survival rate and overall survival rate between the group of triple-negative breast cancer and the group of non-triple-negative breast cancer were com- pared,with statistical significance （P 〈 0.05） , the OR values was respectively 2.48 （95%CI=1.47-4.19）, 2.05 （95%CI= 1.48 -2.85）, 2.19 （95%CI=1.81-2.64）, 1.64 （95%CI=1.16-2.32）, 1.59 （95%CI=1.19-2.13）, 0.49 （95%CI=0.42-0.57）, 0.46 （95%CI=0.39-0.53）. There was no significant difference between the two groups with menopausal status, tumor di- ameter, pathological type （P 〉 0.05）. The OR values was respectively 1.11 （95%CI=0.99-1.25）, 1.23 （95%CI=0.90- 1.68）, 0.87 （95%CI=0.74-1.01）. Conclusion Triple-negative breast cancer are associated with younger disease onset age, higher rate of axillary lymph node positivity, higher tumor histologic grade. It is also related to family history of breast cancer, and 5 years of tumor free survival rate and overall survival rate are lower.

关 键 词：三阴型乳腺癌 病理特征 预后分析 META分析 

分 类 号：R655.8[医药卫生—外科学]