颅骨修补材料研究现状及3D打印技术应用前景  

Research status of skull repair materials and the prospect of three-dimensional printing technology

作　　者：卢磊[1,2] 陈旭义[2,3,4] 李一鹏[1,2] 刚琳 涂悦[2,3,4] 

机构地区：[1]天津中医药大学,天津市300193 [2]天津市神经创伤修复重点实验室,天津市300162 [3]武警后勤学院附属医院脑创伤与神经疾病研究所,天津市300162 [4]武警后勤学院附属医院,天津市300162

出　　处：《中国组织工程研究》2016年第52期7885-7890,共6页Chinese Journal of Tissue Engineering Research

基　　金：天津市科技支撑计划重点项目(14ZCZDGX00500)~~

摘　　要：背景:应用颅骨修补材料不仅能恢复正常的颅骨形态,而且对恢复脑功能有重要意义。目的:对聚醚醚酮、钛合金和组织工程技术在颅骨修补方面的研究现状以及与3D打印技术联合应用的前景做一个总结。方法:检索中国知网数据库、和PubMed数据库1995至2016年发表的有关颅骨修复材料的文献,英文检索词为"bone regeneration material in calvarial,3d printing bone scaffold",中文检索词为"颅骨修补材料,3D打印骨支架"。结果与结论:钛合金和聚醚醚酮材料虽已在临床上使用,但钛合金有导电性、导热性,聚醚醚酮不参与缺损部位骨整合,有脱落或移位的可能。组织工程技术参与颅骨组织重建,修复效果满意,但支架材料选择和制备问题、种子细胞获取问题及生长因子缓释问题需要克服。3D打印技术可个性化打印形状,精确吻合缺损,但对原材料要求高,需要有良好的生物相容性及良好的生物力学性能。组织工程与3D打印技术相结合应用于颅骨修补应用前景广阔。BACKGROUND：Skul repair materials cannot only restore the normal shape of the skul , but also play an important role in brain functional recovery. OBJECTIVE：To summarize the research status of polyetheretherketone （PEEK）, titanium al oy and tissue engineering technique in cranioplasty and the prospect of three-dimensional （3D） printing technology. METHODS：Literatures related to skul repair materials were retrieved in databases of CNKI and PubMed published from 1995 to 2016, using the keywords of“bone regeneration material in calvarial, 3d printing bone scaffold”in Chinese and English, respectively. RESULTS AND CONCLUSION：Although titanium and PEEK have been used in clinic, titanium holds conductivity, thermal conductivity, while PEEK that may be displaced or lost is not involved in osseointegration. Tissue engineering technology participates in the skul tissue reconstruction, achieving satisfactory repair outcomes, but the problems of scaffold selection and preparation, seed cel obtainment, and growth factor release need to be overcomed. 3D printing technology can print personalized shape, fit the defect precisely, but the raw materials should have good biocompatibility and biomechanical property. Combination of tissue engineering technology with 3D printing technology shows a broad prospect in cranioplasty.

关 键 词：颅骨 钛 组织工程 生物材料 骨生物材料 颅骨修补 聚醚醚酮 钛合金 3D打印技术 

分 类 号：R318[医药卫生—生物医学工程]