114例妊娠合并梅毒妊娠结局及母婴阻断效果分析  

Analysis of 114 cases of pregnancy complicated with syphilis pregnancy outcome and maternal and infant blocking effect

作　　者：曾选[1] 陆瑶[1] 汪丽霞[1] 宇翔[1] 

机构地区：[1]江西省妇幼保健院,江西南昌330006

出　　处：《实验与检验医学》2016年第6期720-722,744,共4页Experimental and Laboratory Medicine

基　　金：江西省卫计委课题;编号20155529

摘　　要：目的探讨妊娠期合并梅毒患者不同干预孕周及孕母血清TRUST滴度对孕妇妊娠和围产儿结局的影响。方法选择2013年10月至2016年7月在江西省妇幼保健院诊断、治疗的妊娠合并梅毒患者114例,根据孕期诊断、治疗情况将患者分为<16孕周治疗组(34例)、≥16孕周治疗组(32例)和未治疗组(48例)。采用χ2检验比较各组妊娠结局和围产儿感染情况。结果治疗组与未治疗组在早产、低体重儿、宫内窘迫、胎死宫内、新生儿先天梅毒的发生率差异有统计学差异(P<0.05),流产、新生儿死亡和新生儿畸形的发生率比较差异无统计学意义(P>0.05)。不同孕周治疗组间宫内窘迫、早产、低体重儿、流产、胎死宫内、新生儿死亡、新生儿畸形、新生儿先天梅毒发生率比较差异无统计学意义(P>0.05)。TRUST不同滴度水平下早产、流产、胎死宫内的发生率差异有统计学意义(P<0.05)。结论早发现、早诊断和规范化治疗是改善妊娠结局、降低新生儿死亡和先天梅毒的关键,孕期采取干预措施可取得良好的母婴阻断效果。孕母血清TRUST滴度水平是影响围生儿早产、流产、胎死宫内发生的重要因素。Objective To analyze study the influence of different gestations and toluidine red unheated serum test（TRUST）titer intervention on the outcomes and blocking effect of pregnant women with syphilis.Methods The 114 pregnancy patients with syphilis were divided into some groups,such as less than 16 gestational weeks treatment group（34 patients）,more than 16 gestational weeks（32 patients） and non-treatment group（48 patients）.The differences between groups of outcomes and perinatal infection were statistically analyzed by χ~2test.Results For the incidence rate of premature,low birth weight,fetal distress,intrauterine death,newborn congenital syphilis,there were significant differences between treatment group and non-treatment group（P0.05）.There was no significant difference in the incidence of abortion,perinatal death,congenital malformation between the two groups（P 0.05）.There was no significant difference in the incidence of fetal distress,preterm birth,low birth weight,perinatal death,neonatal death,congenital malformation and congenital syphilis among the groups treated at different gestations times（P 0.05）.Significant differences in perinatal death,abortion and intrauterine death existed among the groups of different TRUST titers（P0.05）.Conclusions Earlier treatment may improve the outcome of pregnancy,and reduce the mortality of infants.Good interventions to pregnant women with syphilis could get the better blocking effect through placenta.Maternal serum TRUST titer is an important factor influencing congenital syphilis and perinatal death.

关 键 词：妊娠期梅毒 发生率 母婴阻断 妊娠结局 

分 类 号：R377.1[医药卫生—病原生物学] R759.1[医药卫生—基础医学]