骨代谢生化指标与绝经后骨质疏松性腰椎骨折相关性分析  

Study of correlation between biochemical markers of bone metabolism and postmenopausal osteoporotic vertebral fractures

作　　者：霍少川[1] 董路珏[2] 唐宏宇[3] 刘勇[2] 郭海[2] 陈建发[3] 邓章荣 陈德龙[2] 王海彬[3] 

机构地区：[1]广州中医药大学第三临床医学院,广州510405 [2]广州中医药大学第一临床医学院,广州510405 [3]广州中医药大学第一附属医院骨科中心,广州510405

出　　处：《重庆医学》2017年第1期48-50,共3页Chongqing medicine

基　　金：国家自然科学基金资助项目(81373655);广东省省级科技计划项目(2013B021800226)

摘　　要：目的探讨骨代谢生化指标与绝经后骨质疏松性腰椎骨折相关性,进而预测绝经后骨质疏松性合并腰椎骨折风险。方法回顾性分析100例绝经后骨质疏松症患者的临床资料,包括绝经后骨质疏松症腰椎无骨折患者50例和绝经后骨质疏松症合并腰椎骨折患者50例,记录并观察髋部、腰椎骨密度、骨代谢生化标志物Ⅰ型前胶原氨基端前肽(P1NP)、Ⅰ型胶原羧基端肽β特殊序列(β-CTX)、骨钙素N端中分子(N-MID)、25-羟基维生素D[25-(OH)VitD]和血清Ca2+。结果P1NP、β-CTX和25-(OH)VitD的差异具有统计学意义(P<0.05),绝经后骨质疏松性腰椎骨折与血清P1NP呈正相关(P<0.05),25-(OH)VitD呈负相关(P<0.05),β-CTX无相关性(P>0.05)。结论骨代谢标志物P1NP、25-(OH)VitD能够很好地预测绝经后骨质疏松腰椎骨折风险,骨密度预测骨质疏松症骨折风险具有一定局限性。Objective To study correlation between biochemical markers of bone metabolism and postmenopausal osteoporotic vertebral fractures. Methods The clinical data of 100 cases with postmenopausal osteoporotic were study retrospectively. Fifty patients were postmenopausal osteoporotic, the rests were postmenopausal osteoporotic vertebral fractures. Lumbar spine, hip BMD,serum P1NP,β-CTX,N-MID,25-（OH）VitD and Ca^2＋ were recorded. Results There was a significant difference among serum P1NP,β-CTX and 25-（OH） VitD （ P 〈 0. 05 ）. There was positive correlation between postmenopausal osteoporotic vertebral fracture with serum P1NP （P〈0.05） ,and negative correlation with serum 25-（OH）VitD （P〈0.05） ,but had no correlation with serum β-CTX （P〈0.05）. Conclusion Serum P1NP and 25-（OH）VitD could predict risk of postmenopausal osteoporotic vertebral fractures. Biochemical markers of bone metabolism combined with BMD could reduce postmenopausal osteoporosis fractures.

关 键 词：骨质疏松 绝经后 绝经后期 骨密度 骨和骨组织 骨代谢生化指标 腰椎骨折 

分 类 号：R580[医药卫生—内分泌] R683[医药卫生—内科学]