^(125)I粒子植入联合动脉灌注化疗治疗晚期胸腺癌的近期疗效评价  

Short-term assessment of ^(125)I seed implantation combined with arterial infusion chemotherapy in treatment of advanced thymic carcinoma

作　　者：王宇鹏[1,2] 宁莉莉[3] 屈波[2] 韩玲[1] 胡永进[1] 许建辉[1] 杜学明[1] 

机构地区：[1]天津市北辰医院肿瘤科,天津300400 [2]中国人民武装警察部队后勤学院附属医院肿瘤科,天津300162 [3]中国人民武装警察部队后勤学院附属医院科研科,天津300162

出　　处：《重庆医学》2017年第1期51-53,共3页Chongqing medicine

基　　金：国家自然科学基金面上项目(81272547);武警后勤学院附属医院种子基金项目(FYM201609)

摘　　要：目的探讨^(125)I粒子植入联合动脉灌注化疗药物治疗晚期胸腺癌的近期评价。方法分析35例经病理细胞学证实Ⅲ~Ⅳ胸腺癌患者,根据治疗手段不同,分为两组:A组18例,采用^(125)I粒子植入联合动脉灌注化疗(NP方案);B组17例,采用动脉灌注化疗治疗。结果两组肿瘤局部控制率(RR)分别为66.7%和47.1%,疾病控制率(DCR)分别为83.3%和64.7%,两组比较差异均有统计学意义(P<0.05)。A、B组治疗后肿瘤患者的生活质量评分(QOL)升高值分别为(12.22±4.67)、(6.12±1.17)分;差异有统计学意义(P<0.05)。A、B组治疗后Karnofsky功能状态评分(Karnofsky,KPS)提高率分别为66.7%、41.2%,差异有统计学意义(P<0.05)。结论采用^(125)I粒子植入联合动脉灌注化疗治疗晚期胸腺癌的近期疗效显著,能够显著提高患者的生活质量。Objective To investigate the short term effect of ^125I seed implantation combined with arterial infusion chemotherapy in the treatment of advanced thymic carcinoma. Methods Thirty-five cases of stage Ⅲ～Ⅳ thymic carcinoma confirmed by cytopathology were selected and divided into two groups according to different treatment means. The group A（18 cases） adopted lz51 seed implantation combined with arterial infusion chemotherapy （NP regimen）. The group B（17 cases） were treated by arterial infusion chemotherapy （NP regimen）. Results The remission rates（RR） in two groups were 66.7% and 47. 1% respectively,and the disease control rates（DCR） were 83.3 % and 64.7% respectively, the differences between the two groups were statistically significant（P〈0.05）. The increment values of quality of life（QOL） scores after treatment in the group A and B were 12.22±4.67 and 6. 12 ±1. 17 respectively, the difference between them was statistically significant （P〈0.05）. The increasing rates of the Karnofsky functional status score （KPS） after treatment in the group A and B were 66.7% and 41.2% respectively,the difference between them was statistically significant （P〈0.05）. Conclusion ^125I seed implantation combined with arterial infusion chemotherapy in the treatment of advanced thymic carcinoma has a remarkable short term effect and can significantly increases the patients; life quality.

关 键 词：碘放射性同位素 输注 动脉内 胸腺肿瘤 手术后期间 ^25I粒子植入 动脉灌注化疗 

分 类 号：R736.3[医药卫生—肿瘤]