聚乙二醇干扰素对慢性乙型肝炎患者听觉功能的影响  

The effect of pegylated interferon on auditory function of patients with chronic hepatitis B

作　　者：鲍诗平[1] 原晶晶[1] 张伟[1] 刘勇刚[1] 焦楠[1] Bao shiping Yuan Jingjing Zhang Wei Liu Yonggang Jiao Nan.(Department of Otolaryngology-Head and Neck, Beijing You ＇an Hospital, Capital Medical University, Beijing 100069, China)

机构地区：[1]首都医科大学附属北京佑安医院耳鼻咽喉头颈外科,100069

出　　处：《北京医学》2016年第12期1295-1297,共3页Beijing Medical Journal

基　　金：丰台区卫生系统科学研究项目(2014-18)

摘　　要：目的探讨慢性乙型肝炎患者应用聚乙二醇干扰素注射液对听觉系统的影响。方法对60例慢性乙型肝炎患者注射干扰素前后进行听觉检查,包括纯音测听、声导抗测听、镫骨肌声反射等,并与60例健康对照组进行比较。结果慢性乙型肝炎患者干扰素治疗前及治疗3个月比较,在250-4 000 Hz平均听阈及250-2 000Hz倍频纯音听阈的差异无统计学意义（P〉0.05）;4 000 Hz听阈由治疗前的（16.63±7.71）d B提高至（18.75±8.14）d B,差异有统计学意义（P〈0.05）。4例慢性乙型肝炎患者出现听力下降,2例出现耳鸣。结论聚乙二醇干扰素可能引起患者高频听力下降。Objective To assess the effects of pegylated interferon therapy on auditory functions of the patients with chronic hepatitis B（CHB）. Methods In a before-after control study, 60 patients with CHB were included. Subjective and objective ototoxicity evaluations via pure tone audiometry, acoustic impedance audiometry, stapedial acoustic reflection were performed one day before and three months after the prescription of the drug. Results There was no significant difference in auditory thresholds at 250-2 000 Hz in patients with CHB before and after 3 months of treatment（P 〈0.05）. The hearing threshold increased from（16.63 ± 7.71） d B to（18.75 ± 8.14） d B at 4 000 Hz after treatment, the difference was statistically significant（P〈0.05）. There were 4 cases of hearing loss, 2 cases had tinnitus during the therapy. Conclusion Pegylated interferon therapy might cause high-frequency hearing loss in some patients.

关 键 词：慢性乙型肝炎 干扰素 听觉功能 纯音测听 

分 类 号：R512.62[医药卫生—内科学]