MicroRNA-30与肾脏损伤  

MicroRNA-30 and kidney injury

作　　者：郎月[1] 刘志红[1] 

机构地区：[1]南京军区南京总医院肾脏科国家肾脏疾病临床医学研究中心全军肾脏病研究所,南京210016

出　　处：《肾脏病与透析肾移植杂志》2016年第6期553-557,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

基　　金：国家重点研发计划项目(2016YFC0904100);江苏省创新能力建设专项(BM2015004)

摘　　要：MicroRNA(miR)是真核动物的一种内源性单链核苷酸,在细胞内起到基因表达的转录后调控作用。micorRNA-30家族由miR-30a^e五个成员组成,不仅在肾脏发育中起重要作用,而且参与了肾脏损伤。miR-30s通过p53、Notch1、钙/钙调磷酸酶通路抑制凋亡与骨架损伤,进而保护足细胞。在肾小管上皮细胞中,miR-30e可调控线粒体的功能,缓解肾间质纤维化。临床分子标志物研究提示,尿miR-30a-5p与原发性局灶节段肾小球硬化患者及原发性肾病综合征患儿疾病活动性相关,并且可预测激素的治疗效果。MicroRNA（ miR） is a kind of endogenous single strand RNA,which post-transcriptionally regulates gene expression in eukaryocyte. MiR-30 family consists of 5 members,miR-30 a through miR-30 e. Previous studies revealed that miR-30 played an important role in kidney development as well as renal injury. Mechanism study demonstrated that they could protect podocyte by reducing apoptosis and cytoskeleton damage via inhibiting p53,Notch1 and calcium / calcineurin pathways. Meanwhile, miR-30 e ameliorated interstitial fibrosis through regulating mitochondrial function in tubular epithelial cells. Clinical studies also suggested that urine miR-30a-5p could serve as a biomarker of adult FSGS and primary nephrotic syndrome in children,which was correlated with activity of disease and therapeutic effect of glucocorticoids.

关 键 词：microRNA-30 肾脏发育 足细胞损伤 间质纤维化 分子标志物 

分 类 号：R692[医药卫生—泌尿科学]