百令胶囊联合脉血康治疗2型糖尿病早期肾病的临床研究  

Clinical research of Bailing capsules combined with Maixuekang capsules in the treatment of type 2 early diabetic nephropathy

作　　者：张远鹏[1] 唐景华[1] 李骏[1] 梁少梅[1] 梁桢[1] 张栋武 

机构地区：[1]佛山市高明区人民医院/广东医科大学附属高明医院,528500

出　　处：《中国实用医药》2016年第32期14-16,共3页China Practical Medicine

基　　金：佛山市医学类科技攻关项目(项目编号:2014AB001034)

摘　　要：目的探讨百令胶囊联合脉血康治疗2型糖尿病早期肾病对患者肾脏生化指标的影响。方法 100例2型糖尿病早期肾病患者,采用随机数字表法分为试验组和对照组,每组50例。对照组采用常规治疗,试验组在常规治疗基础上给予百令胶囊联合脉血康治疗,观察两组在治疗前、治疗后6个月、治疗后1年的肾脏生化指标改变情况。结果治疗前试验组24 h尿白蛋白排泄率(UAER)、尿素(UR)、肌酐(Cr)、胱抑素C(Cys C)指标分别为(298.7±16.6)mg/d、(7.6±0.9)mmol/L、(164.8±15.8)μmol/L、(2.9±0.9)mg/L,与对照组的(289.6±15.8)mg/d、(7.6±0.8)mmol/L、(170.5±14.9)μmol/L、(2.8±0.9)mg/L比较,差异无统计学意义(P>0.05)。治疗6个月及治疗1年后,两组上述指标均优于治疗前,差异有统计学意义(P<0.05);治疗1年后,试验组UAER、Cys C指标优于对照组,差异有统计学意义(P<0.05)。结论百令胶囊联合脉血康胶囊治疗2型糖尿病早期肾病可以显著改善患者的早期症状,较单纯传统疗法效果更佳。Objective To investigate influence by Bailing capsules combined with Maixuekang capsules on renal biochemical indexes in the treatment of type 2 early diabetic nephropathy. Methods A total of 100 patients with type 2 early diabetic nephropathy were divided by random number table into experimental group and control group, with 50 cases in each group. The control group received conventional therapy, and the experimental group received additional Bailing capsules combined with Maixuekang capsules for treatment on the basis of conventional therapy. Observation was made on changes of renal biochemical indexes in both groups before treatment and in 6 months and 1 year after treatment. Results Before treatment, the experimental group had 24 h urinary albumin excretion rate （UAER）, urea （UR）, creatinine （Cr）, and cystatin C （CysC） respectively as （298.7 ± 16.6） mg/d, （7.6 ± 0.9） μmol/L, （164.8 ± 15.8） μmol/L and （2.9 ±0.9） mg/L. Comparing with （289.6 ± 15.8） mg/d, （7.6 ± 0.8） μmol/L, （170.5 ± 14.9） μmol/L and （2.8 ± 0.9） mg/L in the control group, their difference had no statistical significance （P〉0.05）. In 6 months and 1 year after treatment, both groups had better indexes than those before treatment, and the difference had. statistical significance （P〈0.05）. In 1 year after treatment, the experimental group had better UAER and CysC than the control group, and the difference had statistical significance （P〈0.05）. Conclusion Combination of Bailing capsules and Maixuekang capsules in treating type 2early diabetic nephropathy can remarkably improve early symptoms in patients, and it is better than conventional therapy.

关 键 词：百令胶囊 脉血康胶囊 2型糖尿病 早期肾病 肾功能 

分 类 号：R259[医药卫生—中西医结合] R277.5[医药卫生—中医内科学]