理肺汤对过敏性支气管哮喘大鼠肺组织形态学和血清IgE的影响  

Influence of recuperating lung decoction on lung tissue morphology and serum IgE of allergic bronchial asthma rats

作　　者：孔艳华[1,2] 史琦[2] 阎玥[2] 王铁柱[1] 李四维[3] 李春雷[1] 何博[1] 李友林[2] 

机构地区：[1]北京中医药大学,北京100029 [2]中日友好医院,国家中医药管理局重点研究室(肺病慢性咳喘),中医药防治过敏性疾病重点实验室,中医肺病二科,北京100029 [3]西苑医院,北京100091

出　　处：《时珍国医国药》2016年第12期2863-2866,共4页Lishizhen Medicine and Materia Medica Research

基　　金：国家科技支撑计划课题(No.2014BAI10B09);北京市科委十病十药研发项目(No.Z161100001816004);国家自然科学基金青年基金项目(No.81302943)

摘　　要：目的探讨理肺汤对过敏性支气管哮喘大鼠肺组织形态学和血清IgE的作用。方法将40只SD大鼠随机分为空白对照组、模型对照组、理肺汤组、西药(地塞米松)组。采用卵蛋白致敏复制大鼠支气管哮喘模型,各组均给予相应药物灌胃,连续14天。观察大鼠肺组织形态学和血清IgE的变化。结果与空白对照组比较,模型对照组肺组织炎性细胞浸润等病理表现明显,治疗后理肺汤组、西药组肺组织病理形态学得到明显改善。与空白对照组相比,模型对照组BALF涂片嗜酸性粒细胞(EOS)计数显著升高(P<0.01),与模型对照组相比,理肺汤和西药组可显著减少EOS数量(P<0.01)。与空白对照组相比,模型对照组血清IgE水平显著升高(P<0.01),与模型对照组相比,理肺汤和西药组可显著降低血清IgE水平(P<0.01)。结论理肺汤对支气管哮喘大鼠在降低气道高反应性和血清IgE水平、减轻气道炎症以及缓解气道重构等方面有积极的作用。Objective To investigate the influence of recuperating lung decoction on lung tissue morphology and serum IgE of al- lergic bronchial asthma rats. Methods 40 rats were randomly divided into blank control group, model control group, recuperating lung decoction group, western medicine （dexamethasone） group. The rats model of asthma was established by egg protein, each groups were lavage corresponding drugs for 14 days. Observe the changes of lung tissue morphology and serum IgE in rats. Results Compared with the blank control group, inflammatory cell infiltration and other pathological manifestationsin the model group were more obviously, the pathomorphology of lung tissue in the treatment group and Western medicine group were significantly improved after treatment. Compared with the blank control group, the BALF smear （EOS） count in the model group was significantly in- creased （P 〈 0.01 ） , compared with the model group, recuperating lung decoction and dexamethasone can significantly reduce the number of EOS （P 〈0.01 ）. compared with the blank control group, the serum IgE level in the model group was significantly higher than that in the control group （P 〈 0.01 ） , Compared with the model group, lung soup and dexamethasone can significantly reduce the level of serum IgE （P 〈 0.01 ）. Conclusion Recuperating lung decoction has a positive effect on reducing airway hy- perresponsiveness and serum IgE level, alleviating airway inflammation and airway remodeling in rats with bronchial asthma.

关 键 词：理肺汤 支气管哮喘 肺组织形态学 IGE 

分 类 号：R285.5[医药卫生—中药学]