利用液质联用仪检测正常和血瘀证大鼠对莪术醇的代谢差异  

Metabolic differences of curcumol between normal and blood-stasis rats using liquid chromatography-mass spectrometry

作　　者：徐天娇[1] 唐宋琪[2] 荣华[1] 牛英才[1] 

机构地区：[1]齐齐哈尔医学院,黑龙江齐齐哈尔161006 [2]海南医学院,海南海口571199

出　　处：《时珍国医国药》2016年第12期3053-3056,共4页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.81273640);海南省自然科学基金(No.20158283)

摘　　要：目的观察正常和血瘀证大鼠对莪术醇的代谢差异。方法 Wistar雄性大鼠随机分为正常组、血瘀证组、正常+给药组、血瘀证+给药组,利用液质联用仪检测各组大鼠血液、尿液中莪术醇的浓度。结果与正常+给药组比较,血瘀证+给药组大鼠血液中莪术醇的浓度显著降低,差异具有统计学意义(P<0.05)。结论正常和血瘀证大鼠对莪术醇的代谢具有差异,且后者优于前者,符合"有故无殒"的中药辨证减毒理论。Objective This study aims at evaluating the metabolic differences between normal and blood - stasis rats treated with curcumol. Methods Wistar male rats were randomized into four groups, respectively is normal group, blood - stasis model group, normal group treated with curcumol and blood - stasis model group treated with curcumol. Detection of curcumol between normal and blood - stasis rats using liquid chromatography - mass spectrometry. Results blood - stasis model group treated with curcumol were decreased in rats of normal group treated with curcumol （P 〈 0.05）. Conclusion Blood -stasis rats treated with curcumol group can make the metabolic differences below the normal level, and accord with the traditional Chinese medicine theory .

关 键 词：血瘀证 莪术醇 液质联用 

分 类 号：R285.5[医药卫生—中药学]