慢病毒载体介导的基因治疗临床研究进展  

Progress in clinical trials of lentiviral vector-mediated gene therapy

作　　者：王栎程 杨莉[1] 郭丽华[1] 章国卫[1] 

机构地区：[1]杭州师范大学医学院,浙江杭州310036

出　　处：《健康研究》2016年第6期637-640,共4页Health Research

基　　金：国家自然科学基金(81170531);杭州市医疗科研及重点专科专病项目(20110833B30)

摘　　要：慢病毒载体具有高效、安全以及可感染非分裂细胞的优点,是一种基因治疗的重要载体。慢病毒载体介导的基因治疗已获得重大进展并已逐渐进入临床试验阶段,在对多项重要疾病的治疗中获得了显著的疗效,有望成为今后临床治疗的新手段。Lentiviral vector is one kind of important gene therapy vector characteristic of high efficiency,safety and ability to infect non- dividing cells. Great progress has been made in the field of lentiviral vector- mediated gene therapy and the field has advanced to clinical trial. Lentiviral vectors have been applied in the treatment of several major diseases and significant therapeutic effects have been achieved. Gene therapy with lentiviral vectors will become a new technology for clinical practice in the near future.

关 键 词：慢病毒载体 基因治疗 临床研究 

分 类 号：R459.9[医药卫生—治疗学]