肺炎支原体肺炎伴喘息患儿血IL-10、IL-17和VEGF的检测及其意义  

Expression and Significance of IL-10,IL-17 and VEGF in Children with Mycoplasma Pneumoniae Pneumonia Complicated with Wheezing

作　　者：钱胜华[1] 郦银芳[1] 傅雷[2] 何帮顺[2] QIAN Sheng-hua LI Yin-fang FU Lei HE Bang-shun(Department of Pediatrics, Nanjing First Hospital, Nanjing medical University, Nanjing 210006, China)

机构地区：[1]南京医科大学附属南京医院儿科,江苏南京210006 [2]南京医科大学附属南京医院医学检验中心,江苏南京210006

出　　处：《标记免疫分析与临床》2016年第12期1369-1371,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：目的观察白细胞介素10(IL-10)、白细胞介素17(IL-17)和血管内皮生长因子(VEGF)在儿童肺炎支原体肺炎中的表达水平及其与喘息的相关性。方法选取62例肺炎支原体肺炎患儿,分为伴喘息组(A组,32例)和无喘息组(B组,30例),另选取健康儿童30位作为对照组(C组),检测三组儿童血清中IL-10、IL-17和VEGF的浓度。结果肺炎支原体肺炎伴喘息组和无喘息组患儿血清IL-17和VEGF的水平均高于对照组,差异有统计学意义(P<0.01);肺炎支原体肺炎伴喘息患儿的IL-17和VEGF的水平高于不伴喘息者,差异有统计学意义(P<0.01)。与对照组相比,肺炎支原体肺炎伴喘息组和无喘息组患儿的IL-10水平明显降低,差异有统计学意义(P<0.01);肺炎支原体肺炎伴喘息患儿的IL-10的水平低于不伴喘息者,差异有统计学意义(P<0.01)。结论 IL-10、IL-17和VEGF可能在小儿肺炎支原体肺炎导致喘息样发作中起重要作用。Objective To detect serum levels of interleukin-10（ IL-10）,interleukin-17（ IL-17） and vascular endothelial growth factor（ VEGF） in children with mycoplasma pneumoniae（ MP） pneumonia complicated with wheezing. Methods A total of 62 children with MP pneumonia were divided into the group A,with wheezing（ 32 cases） and the group B,without wheezing（ 30 cases）. 30 healthy children were enrolled as control group. Serum levels of IL-10,IL-17 and VEGF were measured by ELISA. Results IL-10 level of group A,B and control group were 8. 5 ± 1. 4ng / L,13. 3 ± 2. 1 ng / L and 18. 6 ± 2. 2ng / L,respectively,The serum IL-17 level of group A,B and control group were 25. 8 ± 2. 1ng / L,16. 6 ± 1. 1 ng / L and 10. 1 ±1. 2ng / L,respectively. The serum VEGF level of group A,B and control group were 2226. 2 ± 110. 1ng / L,1601. 1 ± 114. 3 ng / L and 465. 2 ± 100. 1ng / L,respectively. IL-10,IL-17 and VEGF in both MP groups were significantly higher than that of control group（ P 0. 01）. IL-10,IL-17 and VEGF in MP pneumonia complicated with wheezing were higher than that of MP without wheezing. Conclusion IL-10,IL-17 and VEGF may play important roles in the pathogenesis of MP pneumonia and wheezing attack in children.

关 键 词：肺炎支原体肺炎 支气管哮喘 白细胞介素10 白细胞介素17 血管内皮生长因子 儿童 

分 类 号：R725.6[医药卫生—儿科]