高血压性脑出血患者血清高迁移率族蛋白-1、凝溶胶蛋白、胰岛素样生长因子-1和巨噬细胞移动抑制因子水平变化及其对病情和预后的评估价值  

Changes of serum high mobility group protein-1,insulin like growth factor-1 and macrophage migration inhibitory factor for the assessment of the disease and prognosis in patients with hypertensive cerebral hemorrhage

作　　者：孟亚楠[1] 高萍[1] 李颖蕾 王惠凌[2] 王德超[2] 苏立凯[2] 

机构地区：[1]河北大学临床医学院 [2]河北大学附属医院神经内科,河北保定071000

出　　处：《临床和实验医学杂志》2017年第2期157-159,共3页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨血清高迁移率族蛋白(HMGB)-1、凝溶胶蛋白(GSN)、胰岛素样生长因子-1(IGF-1)和巨噬细胞移动抑制因子(MIF)水平变化及其高血压性脑出血患者病情和预后的临床价值。方法选取于2014年8月至2016年1月就诊的高血压性脑出血患者84例为观察组,将观察组患者根据其神经系统损害情况分为轻度(19例)、中度(42例)、重度(23例)亚组。将同期80例来进行健康体检的志愿者选为对照组。比较观察组与对照组、各亚组患者血清中HMGB-1、GSN、IGF-1和MIF水平,分析各指标与患者预后的关系。结果观察组患者的HMGB-1、MIF水平明显高于对照组患者(P<0.001)。观察组患者的GSN、IGF-1水平明显低于对照组患者(P<0.001)。轻度、中度、重度亚组的脑出血患者血清中GSN、IGF-1、HMGB-1和MIF水平比较差异有显著性(P<0.001)。轻度亚组患者血清中GSN、IGF-1的水平最高其次为中度亚组最低为重度亚组的患者。轻度亚组患者血清中MIF、HMGB-1水平最低其次为中度亚组最高为重度亚组的患者。观察组患者中预后良好的患者46例,预后较差的患者38例。预后良好患者的HMGB-1和MIF水平明显低于预后不良的患者(P<0.001);而GSN和IGF-1水平明显高于预后不良的患者(P<0.001)。结论 IGF-1、GSN、MIF、HMGB-1与高血压性脑出血患者的病情发展密切相关,检测上述指标能够有效评估患者的病情和预后。Objective To investigate the clinical value of serum high mobility group protein- 1,gelsolin,insulin- like growth factor-1 and macrophage migration inhibitory factor in patients with hypertensive cerebral hemorrhage.Methods 84 cases patients with hypertensive cerebral hemorrhage treated in our hospital from August 2014 to January 2016 were selected as the observation group,according to the neurological damage,and were divided into mild（19 cases）,moderate（42 cases） and severe group（23 cases）.80 healthy people in our hospital for physical examination were selected as control group.The levels of IGF- 1,HMGB- 1,GSN and MIF in the serum of each group were compared,and the relationship between the indexes and the prognosis of patients were analyzed.Results The level of HMGB- 1 and MIF in the observation group was significantly higher than that in the control group（P〈 0.001）.The GSN,IGF- 1 levels in observation group of patients were significantly lower than that of the control group（P 〈0.001）.Levels of GSN,IGF- 1,HMGB- 1 and MIF in serum of patients with mild,moderate and severe cerebral hemorrhage had significant difference（P 〈0.001）.The levels of serum GSN and IGF- 1 were the highest in mild subgroup,followed by moderate subgroup,and severe subgroup was the last.The serum levels of MIF and HMGB- 1 were the lowest in mild subgroup,followed by moderate subgroup,with the highest in severe subgroup.In observation group,there were 46 cases with good prognosis,38 cases with poor prognosis.The HMGB- 1 and MIF levels in good prognosis group were significantly lower than those in the poor prognosis group（P〈 0.001）.While GSN and IGF- 1 levels were significantly higher than that of the poor prognosis of patients（P 〈0.001）.Conclusion IGF- 1,GSN,MIF,HMGB- 1 are closely related to the development of the disease in patients with hypertensive cerebral hemorrhage,which can effectively assess the prognosis of patients.

关 键 词：高血压性脑出血 高迁移率族蛋白-1 凝溶胶蛋白 胰岛素样生长因子-1 巨噬细胞移动抑制因子 

分 类 号：R544.1[医药卫生—心血管疾病] R743.34[医药卫生—内科学]