《中医方剂大辞典》含生脉散类方组方规律分析  

Composition Principles of Formula Containing Shengmaisan in Dictionary of Chinese Medicine Prescription

作　　者：耿亚[1,2] 许海玉[2] 马月香[1] 于国华[2,3] 唐仕欢[2] 杨洪军[2] 

机构地区：[1]山东中医药大学基础医学院,济南250355 [2]中国中医科学院中药研究所,北京100700 [3]北京中医药大学药学院,北京100029

出　　处：《中国实验方剂学杂志》2017年第1期200-205,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家"重大新药创制"科技重大专项(2014ZX09201021-009);国家重点基础研究发展计划(973计划)项目(2015CB554406)

摘　　要：目的:应用中医传承辅助平台(V2.5),对《中医方剂大辞典》含生脉散(即人参、麦冬、五味子)类方剂进行组方规律分析,为临床用药及新药研发提供依据。方法:收集整理《中医方剂大辞典》中包含人参、麦冬、五味子的有关方剂,录入中医辅助平台建立数据库,并对其中用药规律、主治疾病进行分析。结果:数据库中共记录有关方剂415首,核心药物组合25个,常与生脉散配伍的中药25味,从中选取血药"当归",气药"黄芪",阴药"山茱萸",阳药"附子"进行药物组合分析,显示生脉散类方虽变化复杂,但总体仍以益气养阴为主,随着配伍方药变化,治疗特点各异。结论:《中医方剂大辞典》中生脉散类方配伍方药广泛,治疗特点明确,多具补益功效;组方规律反应出生脉散类方在治疗不同疾病时的组方特点,对现代临床应用具有指导意义,为生脉散类方现代传承及产品开发提供依据。Objective： To apply TCMISS（V2. 5） to analyze the composition principles of formula containing Shengmaisan in Dictionary of Chinese Medicine Prescription（Ginseng Radix et Rhizoma,Ophiopogonis Radix,Schisandrae Chinensis Fructus） and provide a basis for clinical medication and new drug research and development. Method： Formulas containing Ginseng Radix et Rhizoma, Ophiopogonis Radix and Schisandrae Chinensis Fructus in Dictionary of Chinese Medicine Prescription were collected,sorted and entered TCMISS to build a database and analyze their medication rules and major indications. Result： The database records a total of 415 formulas,25 core drug compositions and 25 TCM compatible with Shengmaisan and selects blood drug ‘Angelicae Sinensis Radix＇,Qi drug ‘Astragali Radix＇,Yin drug ‘Cornt Fructus＇ and Yang drug ‘Aconiti Lateralis Radix Praeparaia＇to analyze drug compositions. It is suggested that although changes in formulas containing Shengmaisan are complex,generally they still give priority to tonifying Qi and Yin. As compatibility changes,the characteristics of treatment differ. Conclusion： Dictionary of Chinese Medicine Prescription has a wide range of compatible drugs for Shengmaisan. The characteristics of treatment are clear. Most of them are tonic and beneficiary. Composition principles reflect the composition features of Shengmaisan when treating different diseases. They have a guiding significance for modern clinical application and provide a basis for modern inheritance and development of formulas containing Shengmai San.

关 键 词：中医方剂大辞典 中医传承辅助平台 生脉散 组方规律 

分 类 号：R287[医药卫生—中药学]